Effect of melatonin in patients with low anterior resection syndrome (MELLARS): a study protocol for a randomised, placebo-controlled, crossover trial

Keyphrases

• Randomized Placebo-controlled Trial 100%
• Melatonin 100%
• Low Anterior Resection Syndrome 100%
• Placebo 25%
• Evacuation 25%
• Bowel Movement 25%
• 25Mg 25%
• Treatment Duration 12%
• Quality of Life 12%
• High Dose 12%
• Histology 12%
• Zealand 12%
• Two-period 12%
• Sleep Disturbance 12%
• Anxiety-depression 12%
• Development Support 12%
• Informed Consent 12%
• Patient-reported Symptoms 12%
• Last Days 12%
• Colorectal Surgery 12%
• First Day 12%
• Anti-inflammatory Properties 12%
• EudraCT 12%
• Ethics Committees 12%
• Rectal mucosa 12%
• Enema 12%
• Peer-reviewed Journals 12%
• Circadian Hormones 12%
• Helsinki 12%
• Feasibility Trial 12%
• Flatus 12%
• Alleviating Effect 12%
• Low Anterior Resection Syndrome Score 12%
• Motilin 12%
• Stool Incontinence 12%

Medicine and Dentistry

• Placebo 100%
• Lower Anterior Resection 100%
• Melatonin 100%
• Symptom 37%
• Evacuation 25%
• Quality of Life 12%
• Rectum Cancer 12%
• Medicine 12%
• Enema 12%
• Incontinence 12%
• Drug Megadose 12%
• Anti-Inflammatory Drug 12%
• Cancer Surgery 12%
• Sleep Disorder 12%
• Informed Consent 12%
• Outcome Assessment 12%
• Sequela 12%
• Flatulence 12%
• Rectum Mucosa 12%
• Motilin 12%