Abstrakt
We investigated the effect of heparin on urinary albumin excretion in patients with insulin-dependent diabetes mellitus. 39 patients with persistent urinary albumin excretion of 30-300 mg/24 h were randomly treated for 3 months with subcutaneous injections twice daily of isotonic saline, 5000 IU unfractionated heparin, or 2000 anti-Xa IU low-molecular-weight heparin. Unfractionated and low-molecular-weight heparin induced a significant reduction in urinary albumin excretion (p = 0.04 and p = 0.004). The mechanism and clinical relevance is unknown but deserve further attention.
Originalsprog | Engelsk |
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Tidsskrift | Lancet |
Vol/bind | 345 |
Udgave nummer | 8947 |
Sider (fra-til) | 421-2 |
Antal sider | 2 |
ISSN | 0140-6736 |
Status | Udgivet - 18 feb. 1995 |