Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Effect of Intracoronary and Intravenous Melatonin on Myocardial Salvage Index in Patients with ST-Elevation Myocardial Infarction: a Randomized Placebo Controlled Trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Pharmacological attenuation of myocardial reperfusion injury in a closed-chest porcine model: a systematic review

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Hypertrophy signaling pathways in experimental chronic aortic regurgitation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Melatonin for preoperative and postoperative anxiety in adults

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. GIP(3-30)NH2 - a tool for the study of GIP physiology

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. More than one-third of Cochrane reviews had gift authors, whereas ghost authorship was rare

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The role of endogenous GIP and GLP-1 in postprandial bone homeostasis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Melatonin has attenuated myocardial ischemia reperfusion injury in experimental studies. We hypothesized that the administration of melatonin during acute myocardial reperfusion improves myocardial salvage index in patients with ST-elevation myocardial infarction. Patients (n = 48) were randomized in a 1:1 ratio to intracoronary and intravenous melatonin (total 50 mg) or placebo. The myocardial salvage index assessed by cardiac magnetic resonance imaging at day 4 (± 1 day) after primary percutaneous coronary intervention was similar in the melatonin group (n = 22) at 55.3% (95% CI 47.0-63.6) and the placebo group (n = 19) at 61.5% (95% CI 57.5-65.5), p = 0.21. The levels of high-sensitive troponin T, creatinine kinase myocardial band, and oxidative biomarkers (advanced oxidation protein products, malondialdehyde, myeloperoxidase) were similar in the groups. The frequency of clinical events at 90 days did not differ between the groups. In conclusion, melatonin did not improve the myocardial salvage index after primary percutaneous coronary intervention in patients with ST elevation myocardial infarction compared with placebo.

OriginalsprogEngelsk
TidsskriftJournal of Cardiovascular Translational Research
Vol/bind10
Udgave nummer5-6
Sider (fra-til)470-479
Antal sider10
ISSN1937-5387
DOI
StatusUdgivet - dec. 2017

ID: 52407312