Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Effect of Increased Potassium Intake on Adrenal Cortical and Cardiovascular Responses to Angiotensin II: A Randomized Crossover Study

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Abnormal Left-Hemispheric Sulcal Patterns in Adults With Simple Congenital Heart Defects Repaired in Childhood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Association Between ECG Abnormalities and Fatal Cardiovascular Disease Among Patients With and Without Severe Mental Illness

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Impact of Plasma Potassium Normalization on Short-Term Mortality in Patients With Hypertension and Hyperkalemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. High-Dose Glucagon Has Hemodynamic Effects Regardless of Cardiac Beta-Adrenoceptor Blockade: A Randomized Clinical Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Arterial hypertension and morphologic abnormalities of cardiac chambers: results from the Copenhagen General Population Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Effect of anti-inflammatory regimen on early postoperative inflammation after cataract surgery

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. The impact of the trajectory of bipolar disorder on global cognitive function: A one-year clinical prospective case-control study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background Increased potassium intake lowers blood pressure in patients with hypertension, but increased potassium intake also elevates plasma concentrations of the blood pressure-raising hormone aldosterone. Besides its well-described renal effects, aldosterone is also believed to have vascular effects, acting through mineralocorticoid receptors present in endothelial and vascular smooth muscle cells, although mineralocorticoid receptors-independent actions are also thought to be involved. Methods and Results To gain further insight into the effect of increased potassium intake and potassium-stimulated hyperaldosteronism on the human cardiovascular system, we conducted a randomized placebo-controlled double-blind crossover study in 25 healthy normotensive men, where 4 weeks treatment with a potassium supplement (90 mmol/day) was compared with 4 weeks on placebo. At the end of each treatment period, we measured potassium and aldosterone in plasma and performed an angiotensin II (AngII) infusion experiment, during which we assessed the aldosterone response in plasma. Hemodynamics were also monitored during the AngII infusion using ECG, impedance cardiography, finger plethysmography (blood pressure-monitoring), and Doppler ultrasound. The study showed that higher potassium intake increased plasma potassium (mean±SD, 4.3±0.2 versus 4.0±0.2 mmol/L; P=0.0002) and aldosterone (median [interquartile range], 440 [336-521] versus 237 [173-386] pmol/L; P<0.0001), and based on a linear mixed model for repeated measurements, increased potassium intake potentiated AngII-stimulated aldosterone secretion (P=0.0020). In contrast, the hemodynamic responses (blood pressure, total peripheral resistance, cardiac output, and renal artery blood flow) to AngII were similar after potassium and placebo. Conclusions Increased potassium intake potentiates AngII-stimulated aldosterone secretion without affecting systemic cardiovascular hemodynamics in healthy normotensive men. Registration EudraCT Number: 2013-004460-66; URL: https://www.ClinicalTrials.gov; Unique identifier: NCT02380157.

OriginalsprogEngelsk
Artikelnummere018716
TidsskriftJournal of the American Heart Association
Vol/bind10
Udgave nummer9
Sider (fra-til)e018716
ISSN2047-9980
DOI
StatusUdgivet - 4 maj 2021

Bibliografisk note

Funding Information:
The present study was supported by The Danish Heart Foundation, The Boserup Foundation (In Danish: Overlaege Johan Boserup og Lise Boserups Legat), The Wedell-Wedellsborgs Foundation (In Danish: Else og Mogens Wedell-Wedellsborgs Fond), a grant from the Danish Hypertension Society

Funding Information:
(sponsored by LEO Pharma A/S), and a research grant from Amager Hvidovre Hospital in Denmark.

ID: 65018177