Effect of Citrullus colocynthis on glycemic factors and lipid profile in type II diabetic patients: a systematic review and meta-analysis

Ali Jafarizadeh, Seyed Amin Raeisi, Nafiseh Ghassab-Abdollahi, Reza Yarani, Mostafa Araj-Khodaei, Mojgan Mirghafourvand*

*Corresponding author af dette arbejde

Abstract

PURPOSE: In this systematic review and meta-analysis, we investigated the effect and side effects of Citrullus colocynthis on glycemic factors and lipid profile in diabetic patients.

METHODS: We systematically searched English and Persian databases from inception till August 2021 using Medical Subject Headings (MeSH). Two authors independently extracted data and assessed the quality of studies. The standardized mean differences were pooled using fixed-effect models, and statistical heterogeneity was assessed using the I squared (I²) index.

RESULTS: Of the 321 articles searched in the databases, 136 related articles were screened, 14 relevant full-text articles were assessed for eligibility; finally, four articles were included in the study, three articles were entered into the meta-analysis. The results of the meta-analysis indicated that Citrullus colocynthis does not have a significant effect on fasting blood sugar (FBS), hemoglobin A1c (HBA1c), low-density lipoprotein (LDL), total cholesterol, and triglyceride indices but increases high-density lipoprotein (HDL) (Mean Difference: 5.76; 95% CI: 1.69 to 9.84; P = 0.006; I2 = 0%).

CONCLUSIONS: The meta-analysis results showed that Citrullus colocynthis has no significant effect on glycemic and metabolic indices of diabetes - except HDL. Due to the relatively low quality and the small number of included trials, conducting further large scale well-designed randomized clinical trials to determine the effect of Citrullus colocynthis on glycemic and metabolic indices seems essential.

SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s40200-022-01045-9.

OriginalsprogEngelsk
TidsskriftJournal of Diabetes and Metabolic Disorders
Vol/bind21
Udgave nummer2
Sider (fra-til)1785-1795
Antal sider11
ISSN2251-6581
DOI
StatusUdgivet - 5 aug. 2022

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