@article{2f5c296d6417466396ca98e135a33782,
title = "Effect modification by population dietary folate on the association between MTHFR genotype, homocysteine, and stroke risk: a meta-analysis of genetic studies and randomised trials",
abstract = "The MTHFR 677C→T polymorphism has been associated with raised homocysteine concentration and increased risk of stroke. A previous overview showed that the effects were greatest in regions with low dietary folate consumption, but differentiation between the effect of folate and small-study bias was difficult. A meta-analysis of randomised trials of homocysteine-lowering interventions showed no reduction in coronary heart disease events or stroke, but the trials were generally set in populations with high folate consumption. We aimed to reduce the effect of small-study bias and investigate whether folate status modifies the association between MTHFR 677C→T and stroke in a genetic analysis and meta-analysis of randomised controlled trials.",
keywords = "Dietary Supplements, Folic Acid, Homocysteine, Humans, Methylenetetrahydrofolate Reductase (NADPH2), Polymorphism, Genetic, Randomized Controlled Trials as Topic, Risk Factors, Stroke, Vitamin B Complex",
author = "Holmes, {Michael V} and Paul Newcombe and Hubacek, {Jaroslav A} and Reecha Sofat and Ricketts, {Sally L} and Jackie Cooper and Breteler, {Monique M B} and Bautista, {Leonelo E} and Pankaj Sharma and Whittaker, {John C} and Liam Smeeth and Fowkes, {F Gerald R} and Ale Algra and Veronika Shmeleva and Zoltan Szolnoki and Mark Roest and Michael Linnebank and Jeppe Zacho and Nalls, {Michael A} and Singleton, {Andrew B} and Luigi Ferrucci and John Hardy and Worrall, {Bradford B} and Rich, {Stephen S} and Mar Matarin and Norman, {Paul E} and Leon Flicker and Almeida, {Osvaldo P} and {van Bockxmeer}, {Frank M} and Hiroshi Shimokata and Kay-Tee Khaw and Wareham, {Nicholas J} and Martin Bobak and Sterne, {Jonathan A C} and Smith, {George Davey} and Talmud, {Philippa J} and {van Duijn}, Cornelia and Humphries, {Steve E} and Price, {Jackie F} and Shah Ebrahim and Lawlor, {Debbie A} and Hankey, {Graeme J} and Meschia, {James F} and Sandhu, {Manjinder S} and Hingorani, {Aroon D} and Casas, {Juan P}",
note = "Copyright {\textcopyright} 2011 Elsevier Ltd. All rights reserved.",
year = "2011",
doi = "10.1016/S0140-6736(11)60872-6",
language = "English",
volume = "378",
pages = "584--94",
journal = "Lancet",
issn = "0140-6736",
publisher = "The/Lancet Publishing Group",
number = "9791",
}