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Region Hovedstaden - en del af Københavns Universitetshospital
E-pub ahead of print

Effect estimates in randomized trials and observational studies: comparing apples with apples

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

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  • INSIGHT START Study Group and the HIV-CAUSAL Collaboration
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Effect estimates from randomized trials and observational studies may not be directly comparable because of differences in study design, other than randomization, and in data analysis. We propose a three-step procedure to facilitate meaningful comparisons of effect estimates from randomized trials and observational studies: 1) harmonization of the study protocol (eligibility criteria, treatment strategies, outcome, start and end of follow-up, causal contrast) so that the studies target the same causal effect, 2) harmonization of the data analysis to estimate the causal effect, and 3) sensitivity analyses to investigate the impact of discrepancies that could not be accounted for in the harmonization process. To illustrate our approach, we compared estimates of the effect of immediate with deferred initiation of antiretroviral therapy in individuals positive to the human immunodeficiency virus from the START randomized trial and the observational HIV-CAUSAL Collaboration.

OriginalsprogEngelsk
TidsskriftAmerican Journal of Epidemiology
ISSN0002-9262
DOI
StatusE-pub ahead of print - 7 maj 2019

Bibliografisk note

© The Author(s) 2019. Published by Oxford University Press on behalf of the Johns Hopkins Bloomberg School of Public Health. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

ID: 57115856