ECT: its brain enabling effects: a review of electroconvulsive therapy-induced structural brain plasticity

Filip Bouckaert; Pascal Sienaert; Jasmien Obbels; Annemieke Dols; Mathieu Vandenbulcke; Max Stek; Tom Bolwig

doi:10.1097/YCT.0000000000000129

ECT: its brain enabling effects: a review of electroconvulsive therapy-induced structural brain plasticity

Filip Bouckaert, Pascal Sienaert, Jasmien Obbels, Annemieke Dols, Mathieu Vandenbulcke, Max Stek, Tom Bolwig

Psykiatrisk Center København

143 Citationer (Scopus)

Abstract

BACKGROUND: Since the past 2 decades, new evidence for brain plasticity has caused a shift in both preclinical and clinical ECT research from falsifying the "brain damage hypothesis" toward exploring ECT's enabling brain (neuro)plasticity effects.

METHODS: By reviewing the available animal and human literature, we examined the theory that seizure-induced structural changes are crucial for the therapeutic efficacy of ECT.

RESULTS: Both animal and human studies suggest electroconvulsive stimulation/electroconvulsive therapy (ECT)-related neuroplasticity (neurogenesis, synaptogenesis, angiogenesis, or gliogenesis).

CONCLUSION: It remains unclear whether structural changes might explain the therapeutic efficacy and/or be related to the (transient) learning and memory impairment after ECT. Methods to assess in vivo brain plasticity of patients treated with ECT will be of particular importance for future longitudinal studies to give support to the currently available correlational data.

Originalsprog	Engelsk
Tidsskrift	The journal of ECT
Vol/bind	30
Udgave nummer	2
Sider (fra-til)	143-51
Antal sider	9
ISSN	1095-0680
DOI	https://doi.org/10.1097/YCT.0000000000000129
Status	Udgivet - jun. 2014

Adgang til dokumentet

10.1097/YCT.0000000000000129

Citationsformater

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keywords = "Animals, Brain, Depression, Electroconvulsive Therapy, Humans, Neuronal Plasticity",

author = "Filip Bouckaert and Pascal Sienaert and Jasmien Obbels and Annemieke Dols and Mathieu Vandenbulcke and Max Stek and Tom Bolwig",

year = "2014",

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TY - JOUR

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T2 - its brain enabling effects: a review of electroconvulsive therapy-induced structural brain plasticity

AU - Bouckaert, Filip

AU - Sienaert, Pascal

AU - Obbels, Jasmien

AU - Dols, Annemieke

AU - Vandenbulcke, Mathieu

AU - Stek, Max

AU - Bolwig, Tom

PY - 2014/6

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N2 - BACKGROUND: Since the past 2 decades, new evidence for brain plasticity has caused a shift in both preclinical and clinical ECT research from falsifying the "brain damage hypothesis" toward exploring ECT's enabling brain (neuro)plasticity effects.METHODS: By reviewing the available animal and human literature, we examined the theory that seizure-induced structural changes are crucial for the therapeutic efficacy of ECT.RESULTS: Both animal and human studies suggest electroconvulsive stimulation/electroconvulsive therapy (ECT)-related neuroplasticity (neurogenesis, synaptogenesis, angiogenesis, or gliogenesis).CONCLUSION: It remains unclear whether structural changes might explain the therapeutic efficacy and/or be related to the (transient) learning and memory impairment after ECT. Methods to assess in vivo brain plasticity of patients treated with ECT will be of particular importance for future longitudinal studies to give support to the currently available correlational data.

AB - BACKGROUND: Since the past 2 decades, new evidence for brain plasticity has caused a shift in both preclinical and clinical ECT research from falsifying the "brain damage hypothesis" toward exploring ECT's enabling brain (neuro)plasticity effects.METHODS: By reviewing the available animal and human literature, we examined the theory that seizure-induced structural changes are crucial for the therapeutic efficacy of ECT.RESULTS: Both animal and human studies suggest electroconvulsive stimulation/electroconvulsive therapy (ECT)-related neuroplasticity (neurogenesis, synaptogenesis, angiogenesis, or gliogenesis).CONCLUSION: It remains unclear whether structural changes might explain the therapeutic efficacy and/or be related to the (transient) learning and memory impairment after ECT. Methods to assess in vivo brain plasticity of patients treated with ECT will be of particular importance for future longitudinal studies to give support to the currently available correlational data.

KW - Animals

KW - Brain

KW - Depression

KW - Electroconvulsive Therapy

KW - Humans

KW - Neuronal Plasticity

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DO - 10.1097/YCT.0000000000000129

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SN - 1095-0680

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SP - 143

EP - 151

JO - The journal of ECT

JF - The journal of ECT

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ER -

ECT: its brain enabling effects: a review of electroconvulsive therapy-induced structural brain plasticity

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