Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study

Trine K Lauridsen; Lawrence Park; Steven Y C Tong; Christine Selton-Suty; Gail Peterson; Enrico Cecchi; Luis Afonso; Gilbert Habib; Carlos Paré; Syahidah Tamin; Stuart Dickerman; Arnold S Bayer; Magnus C Johansson; Vivian H Chu; Zainab Samad; Niels Eske Bruun; Vance G Fowler; Anna Lisa Crowley

doi:10.1161/CIRCIMAGING.114.003397

Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study

Trine K Lauridsen, Lawrence Park, Steven Y C Tong, Christine Selton-Suty, Gail Peterson, Enrico Cecchi, Luis Afonso, Gilbert Habib, Carlos Paré, Syahidah Tamin, Stuart Dickerman, Arnold S Bayer, Magnus C Johansson, Vivian H Chu, Zainab Samad, Niels Eske Bruun, Vance G Fowler, Anna Lisa Crowley

Hjertesygdomme

46 Citationer (Scopus)

Abstract

BACKGROUND: Staphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in S aureus LNVIE is unknown.

METHODS AND RESULTS: Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without S aureus IE were matched to those with S aureus IE by the propensity of having S aureus. Survival differences were determined using log-rank significance tests. Independent echocardiographic predictors of mortality were identified using Cox-proportional hazards models that included inverse probability of treatment weighting and surgery as a time-dependent covariate. Of 727 subjects with LNVIE and 1-year follow-up, 202 had S aureus IE. One-year survival rates were significantly lower for patients with S aureus IE overall (57% S aureus IE versus 80% non-S aureus IE; P<0.001) and in the propensity-matched cohort (59% S aureus IE versus 68% non-S aureus IE; P<0.05). Intracardiac abscess (hazard ratio, 2.93; 95% confidence interval, 1.52-5.40; P<0.001) and left ventricular ejection fraction <40% (odds ratio, 3.01; 95% confidence interval, 1.35-6.04; P=0.004) were the only independent echocardiographic predictors of in-hospital mortality in S aureus LNVIE. Valve perforation (hazard ratio, 2.16; 95% confidence interval, 1.21-3.68; P=0.006) and intracardiac abscess (hazard ratio, 2.25; 95% confidence interval, 1.26-3.78; P=0.004) were the only independent predictors of 1-year mortality.

CONCLUSIONS: S aureus is an independent predictor of 1-year mortality in subjects with LNVIE. In S aureus LNVIE, intracardiac abscess and left ventricular ejection fraction <40% independently predicted in-hospital mortality and intracardiac abscess and valve perforation independently predicted 1-year mortality.

Originalsprog	Engelsk
Tidsskrift	Circulation. Cardiovascular Imaging
Vol/bind	8
Udgave nummer	7
Sider (fra-til)	e003397
ISSN	1941-9651
DOI	https://doi.org/10.1161/CIRCIMAGING.114.003397
Status	Udgivet - jul. 2015

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Citationsformater

Lauridsen, T. K., Park, L., Tong, S. Y. C., Selton-Suty, C., Peterson, G., Cecchi, E., Afonso, L., Habib, G., Paré, C., Tamin, S., Dickerman, S., Bayer, A. S., Johansson, M. C., Chu, V. H., Samad, Z., Bruun, N. E., Fowler, V. G., & Crowley, A. L. (2015). Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study. Circulation. Cardiovascular Imaging, 8(7), e003397. https://doi.org/10.1161/CIRCIMAGING.114.003397

Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study. / Lauridsen, Trine K; Park, Lawrence; Tong, Steven Y C et al.
I: Circulation. Cardiovascular Imaging, Bind 8, Nr. 7, 07.2015, s. e003397.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Lauridsen, TK, Park, L, Tong, SYC, Selton-Suty, C, Peterson, G, Cecchi, E, Afonso, L, Habib, G, Paré, C, Tamin, S, Dickerman, S, Bayer, AS, Johansson, MC, Chu, VH, Samad, Z, Bruun, NE, Fowler, VG & Crowley, AL 2015, 'Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study', Circulation. Cardiovascular Imaging, bind 8, nr. 7, s. e003397. https://doi.org/10.1161/CIRCIMAGING.114.003397

Lauridsen TK, Park L, Tong SYC, Selton-Suty C, Peterson G, Cecchi E et al. Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study. Circulation. Cardiovascular Imaging. 2015 jul.;8(7):e003397. doi: 10.1161/CIRCIMAGING.114.003397

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title = "Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis: Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study",

abstract = "BACKGROUND: Staphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in S aureus LNVIE is unknown.METHODS AND RESULTS: Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without S aureus IE were matched to those with S aureus IE by the propensity of having S aureus. Survival differences were determined using log-rank significance tests. Independent echocardiographic predictors of mortality were identified using Cox-proportional hazards models that included inverse probability of treatment weighting and surgery as a time-dependent covariate. Of 727 subjects with LNVIE and 1-year follow-up, 202 had S aureus IE. One-year survival rates were significantly lower for patients with S aureus IE overall (57% S aureus IE versus 80% non-S aureus IE; P<0.001) and in the propensity-matched cohort (59% S aureus IE versus 68% non-S aureus IE; P<0.05). Intracardiac abscess (hazard ratio, 2.93; 95% confidence interval, 1.52-5.40; P<0.001) and left ventricular ejection fraction <40% (odds ratio, 3.01; 95% confidence interval, 1.35-6.04; P=0.004) were the only independent echocardiographic predictors of in-hospital mortality in S aureus LNVIE. Valve perforation (hazard ratio, 2.16; 95% confidence interval, 1.21-3.68; P=0.006) and intracardiac abscess (hazard ratio, 2.25; 95% confidence interval, 1.26-3.78; P=0.004) were the only independent predictors of 1-year mortality.CONCLUSIONS: S aureus is an independent predictor of 1-year mortality in subjects with LNVIE. In S aureus LNVIE, intracardiac abscess and left ventricular ejection fraction <40% independently predicted in-hospital mortality and intracardiac abscess and valve perforation independently predicted 1-year mortality.",

keywords = "Abscess, Adult, Aged, Case-Control Studies, Cooperative Behavior, Echocardiography, Transesophageal, Endocarditis, Bacterial, Female, Hospital Mortality, Humans, International Cooperation, Kaplan-Meier Estimate, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Predictive Value of Tests, Prognosis, Proportional Hazards Models, Prospective Studies, Registries, Risk Assessment, Risk Factors, Staphylococcal Infections, Stroke Volume, Ventricular Function, Left",

author = "Lauridsen, {Trine K} and Lawrence Park and Tong, {Steven Y C} and Christine Selton-Suty and Gail Peterson and Enrico Cecchi and Luis Afonso and Gilbert Habib and Carlos Par{\'e} and Syahidah Tamin and Stuart Dickerman and Bayer, {Arnold S} and Johansson, {Magnus C} and Chu, {Vivian H} and Zainab Samad and Bruun, {Niels Eske} and Fowler, {Vance G} and Crowley, {Anna Lisa}",

note = "{\textcopyright} 2015 American Heart Association, Inc.",

year = "2015",

month = jul,

doi = "10.1161/CIRCIMAGING.114.003397",

language = "English",

volume = "8",

pages = "e003397",

journal = "Circulation. Cardiovascular Imaging",

issn = "1941-9651",

publisher = "Lippincott Williams and Wilkins",

number = "7",

}

TY - JOUR

T1 - Echocardiographic Findings Predict In-Hospital and 1-Year Mortality in Left-Sided Native Valve Staphylococcus aureus Endocarditis

T2 - Analysis From the International Collaboration on Endocarditis-Prospective Echo Cohort Study

AU - Lauridsen, Trine K

AU - Park, Lawrence

AU - Tong, Steven Y C

AU - Selton-Suty, Christine

AU - Peterson, Gail

AU - Cecchi, Enrico

AU - Afonso, Luis

AU - Habib, Gilbert

AU - Paré, Carlos

AU - Tamin, Syahidah

AU - Dickerman, Stuart

AU - Bayer, Arnold S

AU - Johansson, Magnus C

AU - Chu, Vivian H

AU - Samad, Zainab

AU - Bruun, Niels Eske

AU - Fowler, Vance G

AU - Crowley, Anna Lisa

PY - 2015/7

Y1 - 2015/7

N2 - BACKGROUND: Staphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in S aureus LNVIE is unknown.METHODS AND RESULTS: Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without S aureus IE were matched to those with S aureus IE by the propensity of having S aureus. Survival differences were determined using log-rank significance tests. Independent echocardiographic predictors of mortality were identified using Cox-proportional hazards models that included inverse probability of treatment weighting and surgery as a time-dependent covariate. Of 727 subjects with LNVIE and 1-year follow-up, 202 had S aureus IE. One-year survival rates were significantly lower for patients with S aureus IE overall (57% S aureus IE versus 80% non-S aureus IE; P<0.001) and in the propensity-matched cohort (59% S aureus IE versus 68% non-S aureus IE; P<0.05). Intracardiac abscess (hazard ratio, 2.93; 95% confidence interval, 1.52-5.40; P<0.001) and left ventricular ejection fraction <40% (odds ratio, 3.01; 95% confidence interval, 1.35-6.04; P=0.004) were the only independent echocardiographic predictors of in-hospital mortality in S aureus LNVIE. Valve perforation (hazard ratio, 2.16; 95% confidence interval, 1.21-3.68; P=0.006) and intracardiac abscess (hazard ratio, 2.25; 95% confidence interval, 1.26-3.78; P=0.004) were the only independent predictors of 1-year mortality.CONCLUSIONS: S aureus is an independent predictor of 1-year mortality in subjects with LNVIE. In S aureus LNVIE, intracardiac abscess and left ventricular ejection fraction <40% independently predicted in-hospital mortality and intracardiac abscess and valve perforation independently predicted 1-year mortality.

AB - BACKGROUND: Staphylococcus aureus left-sided native valve infective endocarditis (LNVIE) has higher complication and mortality rates compared with endocarditis from other pathogens. Whether echocardiographic variables can predict prognosis in S aureus LNVIE is unknown.METHODS AND RESULTS: Consecutive patients with LNVIE, enrolled between January 2000 and September 2006, in the International Collaboration on Endocarditis were identified. Subjects without S aureus IE were matched to those with S aureus IE by the propensity of having S aureus. Survival differences were determined using log-rank significance tests. Independent echocardiographic predictors of mortality were identified using Cox-proportional hazards models that included inverse probability of treatment weighting and surgery as a time-dependent covariate. Of 727 subjects with LNVIE and 1-year follow-up, 202 had S aureus IE. One-year survival rates were significantly lower for patients with S aureus IE overall (57% S aureus IE versus 80% non-S aureus IE; P<0.001) and in the propensity-matched cohort (59% S aureus IE versus 68% non-S aureus IE; P<0.05). Intracardiac abscess (hazard ratio, 2.93; 95% confidence interval, 1.52-5.40; P<0.001) and left ventricular ejection fraction <40% (odds ratio, 3.01; 95% confidence interval, 1.35-6.04; P=0.004) were the only independent echocardiographic predictors of in-hospital mortality in S aureus LNVIE. Valve perforation (hazard ratio, 2.16; 95% confidence interval, 1.21-3.68; P=0.006) and intracardiac abscess (hazard ratio, 2.25; 95% confidence interval, 1.26-3.78; P=0.004) were the only independent predictors of 1-year mortality.CONCLUSIONS: S aureus is an independent predictor of 1-year mortality in subjects with LNVIE. In S aureus LNVIE, intracardiac abscess and left ventricular ejection fraction <40% independently predicted in-hospital mortality and intracardiac abscess and valve perforation independently predicted 1-year mortality.

KW - Abscess

KW - Adult

KW - Aged

KW - Case-Control Studies

KW - Cooperative Behavior

KW - Echocardiography, Transesophageal

KW - Endocarditis, Bacterial

KW - Female

KW - Hospital Mortality

KW - Humans

KW - International Cooperation

KW - Kaplan-Meier Estimate

KW - Logistic Models

KW - Male

KW - Middle Aged

KW - Multivariate Analysis

KW - Odds Ratio

KW - Predictive Value of Tests

KW - Prognosis

KW - Proportional Hazards Models

KW - Prospective Studies

KW - Registries

KW - Risk Assessment

KW - Risk Factors

KW - Staphylococcal Infections

KW - Stroke Volume

KW - Ventricular Function, Left

U2 - 10.1161/CIRCIMAGING.114.003397

DO - 10.1161/CIRCIMAGING.114.003397

M3 - Journal article

C2 - 26162783

SN - 1941-9651

VL - 8

SP - e003397

JO - Circulation. Cardiovascular Imaging

JF - Circulation. Cardiovascular Imaging

IS - 7

ER -