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Early-life childhood obesity risk prediction: A Danish register-based cohort study exploring the predictive value of infancy weight gain

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Rotevatn, T. A., Mortensen, R. N., Ullits, L. R., Torp-Pedersen, C., Overgaard, C., Høstgaard, A. M. B., & Bøggild, H. (2021). Early-life childhood obesity risk prediction: A Danish register-based cohort study exploring the predictive value of infancy weight gain. Pediatric obesity, 16(10), e12790. [e12790]. https://doi.org/10.1111/ijpo.12790

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Author

Rotevatn, Torill Alise ; Mortensen, Rikke Nørmark ; Ullits, Line Rosenkilde ; Torp-Pedersen, Christian ; Overgaard, Charlotte ; Høstgaard, Anna Marie Balling ; Bøggild, Henrik. / Early-life childhood obesity risk prediction : A Danish register-based cohort study exploring the predictive value of infancy weight gain. I: Pediatric obesity. 2021 ; Bind 16, Nr. 10. s. e12790.

Bibtex

@article{0d0cc5b37c62441cafbe2e638df6555f,
title = "Early-life childhood obesity risk prediction: A Danish register-based cohort study exploring the predictive value of infancy weight gain",
abstract = "BACKGROUND: Information on postnatal weight gain is important for predicting later overweight and obesity, but it is unclear whether inclusion of this postnatal predictor improves the predictive performance of a comprehensive model based on prenatal and birth-related predictors.OBJECTIVES: To compare performance of prediction models based on predictors available at birth, with and without information on infancy weight gain during the first year when predicting childhood obesity risk.METHODS: A Danish register-based cohort study including 55.041 term children born between January 2004 and July 2011 with birthweight >2500 g registered in The Children's Database was used to compare model discrimination, reclassification, sensitivity and specificity of two models predicting risk of childhood obesity at school age. Each model consisted of eight predictors available at birth, one additionally including information on weight gain during the first 12 months of life.RESULTS: The area under the receiving operating characteristic curve increased from 0.785 (95% confidence interval (CI) [0.773-0.798]) to 0.812 (95% CI [0.801-0.824]) after adding weight gain information when predicting childhood obesity. Adding this information correctly classified 30% more children without obesity and 21% with obesity and improved sensitivity from 0.42 to 0.48. Specificity remained unchanged at 0.91.CONCLUSION: Adding infancy weight gain information improves discrimination, reclassification and sensitivity of a comprehensive prediction model based on predictors available at birth.",
keywords = "childhood obesity, infancy weight gain, overweight, prediction, risk factors",
author = "Rotevatn, {Torill Alise} and Mortensen, {Rikke N{\o}rmark} and Ullits, {Line Rosenkilde} and Christian Torp-Pedersen and Charlotte Overgaard and H{\o}stgaard, {Anna Marie Balling} and Henrik B{\o}ggild",
note = "{\textcopyright} 2021 World Obesity Federation.",
year = "2021",
month = oct,
doi = "10.1111/ijpo.12790",
language = "English",
volume = "16",
pages = "e12790",
journal = "International Journal of Pediatric Obesity",
issn = "1524-6817",
publisher = "Wiley-Blackwell for the International Association for the Study of Obesity",
number = "10",

}

RIS

TY - JOUR

T1 - Early-life childhood obesity risk prediction

T2 - A Danish register-based cohort study exploring the predictive value of infancy weight gain

AU - Rotevatn, Torill Alise

AU - Mortensen, Rikke Nørmark

AU - Ullits, Line Rosenkilde

AU - Torp-Pedersen, Christian

AU - Overgaard, Charlotte

AU - Høstgaard, Anna Marie Balling

AU - Bøggild, Henrik

N1 - © 2021 World Obesity Federation.

PY - 2021/10

Y1 - 2021/10

N2 - BACKGROUND: Information on postnatal weight gain is important for predicting later overweight and obesity, but it is unclear whether inclusion of this postnatal predictor improves the predictive performance of a comprehensive model based on prenatal and birth-related predictors.OBJECTIVES: To compare performance of prediction models based on predictors available at birth, with and without information on infancy weight gain during the first year when predicting childhood obesity risk.METHODS: A Danish register-based cohort study including 55.041 term children born between January 2004 and July 2011 with birthweight >2500 g registered in The Children's Database was used to compare model discrimination, reclassification, sensitivity and specificity of two models predicting risk of childhood obesity at school age. Each model consisted of eight predictors available at birth, one additionally including information on weight gain during the first 12 months of life.RESULTS: The area under the receiving operating characteristic curve increased from 0.785 (95% confidence interval (CI) [0.773-0.798]) to 0.812 (95% CI [0.801-0.824]) after adding weight gain information when predicting childhood obesity. Adding this information correctly classified 30% more children without obesity and 21% with obesity and improved sensitivity from 0.42 to 0.48. Specificity remained unchanged at 0.91.CONCLUSION: Adding infancy weight gain information improves discrimination, reclassification and sensitivity of a comprehensive prediction model based on predictors available at birth.

AB - BACKGROUND: Information on postnatal weight gain is important for predicting later overweight and obesity, but it is unclear whether inclusion of this postnatal predictor improves the predictive performance of a comprehensive model based on prenatal and birth-related predictors.OBJECTIVES: To compare performance of prediction models based on predictors available at birth, with and without information on infancy weight gain during the first year when predicting childhood obesity risk.METHODS: A Danish register-based cohort study including 55.041 term children born between January 2004 and July 2011 with birthweight >2500 g registered in The Children's Database was used to compare model discrimination, reclassification, sensitivity and specificity of two models predicting risk of childhood obesity at school age. Each model consisted of eight predictors available at birth, one additionally including information on weight gain during the first 12 months of life.RESULTS: The area under the receiving operating characteristic curve increased from 0.785 (95% confidence interval (CI) [0.773-0.798]) to 0.812 (95% CI [0.801-0.824]) after adding weight gain information when predicting childhood obesity. Adding this information correctly classified 30% more children without obesity and 21% with obesity and improved sensitivity from 0.42 to 0.48. Specificity remained unchanged at 0.91.CONCLUSION: Adding infancy weight gain information improves discrimination, reclassification and sensitivity of a comprehensive prediction model based on predictors available at birth.

KW - childhood obesity

KW - infancy weight gain

KW - overweight

KW - prediction

KW - risk factors

UR - http://www.scopus.com/inward/record.url?scp=85103403067&partnerID=8YFLogxK

U2 - 10.1111/ijpo.12790

DO - 10.1111/ijpo.12790

M3 - Journal article

C2 - 33783137

VL - 16

SP - e12790

JO - International Journal of Pediatric Obesity

JF - International Journal of Pediatric Obesity

SN - 1524-6817

IS - 10

M1 - e12790

ER -

ID: 64684862