Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Early trigeminal nerve involvement in Listeria monocytogenes rhombencephalitis: case series and systematic review

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Diagnostic interest of whole-body MRI in early- and late-onset LAMA2 muscular dystrophies: a large international cohort

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Central and peripheral nervous system complications of COVID-19: a prospective tertiary center cohort with 3-month follow-up

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Frequency of fatigue and its changes in the first 6 months after traumatic brain injury: results from the CENTER-TBI study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Characteristic muscle signatures assessed by quantitative MRI in patients with Bethlem myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Interventions for altering blood pressure in people with acute subarachnoid haemorrhage

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Questionnaires vs Interviews for the Assessment of Global Functional Outcomes After Traumatic Brain Injury

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Listeria monocytogenes is associated with rhombencephalitis. However, the exact mechanisms of brainstem invasion remains poorly understood. Here, we demonstrate clinical and radiological data suggesting that Listeria may invade the brainstem via the trigeminal nerve. Three females (41, 64 and 70 years) with culture proven L. monocytogenes bacteremia and rhombencephalitis were investigated in the period of 2014-16. T2-weighted and contrast-enhanced T1-weighted MRI revealed a cerebellopontine abscess in all three patients, including the involvement of the trigeminal nerve root. In two patients, MRI also revealed selective contrast enhancement of the sensory trigeminal tract in the pons and medulla oblongata. Prior to any other neurological symptoms, two patients complained of hypoesthesia and a tingling sensation in the ipsilateral half of the face, consistent with sensory trigeminal nerve dysfunction on that side. In addition, we identified another 120 cases of Listeria rhombencephalitis following a systematic review. Cranial nerves VII, V, IX, and X, respectively, medulla oblongata, cerebellum and pons, were the most frequently involved brain structures. The present clinical and radiological findings corroborate earlier data from animal experiments, indicating that L. monocytogenes may be capable of retrograde intra-axonal migration along the cranial nerves. We suggest that in a subset of patients with rhombencephalitis L. monocytogenes enters the cerebellopontine angle through the trigeminal nerve, invading the brainstem via the sensory trigeminal nuclei.

OriginalsprogEngelsk
TidsskriftJournal of Neurology
Vol/bind264
Udgave nummer9
Sider (fra-til)1875-1884
Antal sider10
ISSN0340-5354
DOI
StatusUdgivet - sep. 2017

ID: 52105108