Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects

Anni Larnkjaer; Helga Kristensen Ingstrup; Lene Schack-Nielsen; Camilla Hoppe; Christian Mølgaard; Ib Skovgaard; Anders Juul; Kim F Michaelsen

doi:10.1016/j.ghir.2008.06.003

Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects

Anni Larnkjaer, Helga Kristensen Ingstrup, Lene Schack-Nielsen, Camilla Hoppe, Christian Mølgaard, Ib Skovgaard, Anders Juul, Kim F Michaelsen

54 Citationer (Scopus)

Abstract

IGF-I is a major regulator of growth, influenced primarily by diet in infancy and primarily by GH in childhood. Breastfed infants have lower IGF-I levels compared to formula fed and tend to be shorter. The higher protein content of infant formula has a stimulatory effect on IGF-I production. Conversely, studies suggest that later in childhood, those breastfed are taller and have higher IGF-I levels. Therefore, it has been suggested that the IGF-I axis may be programmed by diet during infancy. The association between IGF-I in infancy and later life is not known.

Originalsprog	Engelsk
Tidsskrift	Growth Hormone & I G F Research
Vol/bind	19
Udgave nummer	1
Sider (fra-til)	82-6
Antal sider	5
ISSN	1096-6374
DOI	https://doi.org/10.1016/j.ghir.2008.06.003
Status	Udgivet - 2009
Udgivet eksternt	Ja

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10.1016/j.ghir.2008.06.003

Citationsformater

Larnkjaer, A., Ingstrup, H. K., Schack-Nielsen, L., Hoppe, C., Mølgaard, C., Skovgaard, I., Juul, A., & Michaelsen, K. F. (2009). Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects. Growth Hormone & I G F Research, 19(1), 82-6. https://doi.org/10.1016/j.ghir.2008.06.003

Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects. / Larnkjaer, Anni; Ingstrup, Helga Kristensen; Schack-Nielsen, Lene et al.
I: Growth Hormone & I G F Research, Bind 19, Nr. 1, 2009, s. 82-6.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Larnkjaer, A, Ingstrup, HK, Schack-Nielsen, L, Hoppe, C, Mølgaard, C, Skovgaard, I, Juul, A & Michaelsen, KF 2009, 'Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects', Growth Hormone & I G F Research, bind 19, nr. 1, s. 82-6. https://doi.org/10.1016/j.ghir.2008.06.003

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T2 - negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects

AU - Larnkjaer, Anni

AU - Ingstrup, Helga Kristensen

AU - Schack-Nielsen, Lene

AU - Hoppe, Camilla

AU - Mølgaard, Christian

AU - Skovgaard, Ib

AU - Juul, Anders

AU - Michaelsen, Kim F

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AB - IGF-I is a major regulator of growth, influenced primarily by diet in infancy and primarily by GH in childhood. Breastfed infants have lower IGF-I levels compared to formula fed and tend to be shorter. The higher protein content of infant formula has a stimulatory effect on IGF-I production. Conversely, studies suggest that later in childhood, those breastfed are taller and have higher IGF-I levels. Therefore, it has been suggested that the IGF-I axis may be programmed by diet during infancy. The association between IGF-I in infancy and later life is not known.

KW - Adolescent

KW - Age Factors

KW - Diet

KW - Female

KW - Follow-Up Studies

KW - Growth

KW - Humans

KW - Infant

KW - Insulin-Like Growth Factor I

KW - Longitudinal Studies

KW - Male

U2 - 10.1016/j.ghir.2008.06.003

DO - 10.1016/j.ghir.2008.06.003

M3 - Journal article

C2 - 18662893

SN - 1096-6374

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JO - Growth Hormone & I G F Research

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Early programming of the IGF-I axis: negative association between IGF-I in infancy and late adolescence in a 17-year longitudinal follow-up study of healthy subjects

Abstract

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