Early onset type 2 diabetes: Age gradient in Clinical and Behavioural Risk Factors in 5115 Persons with Newly Diagnosed Type 2 Diabetes - Results from the DD2 study

A Bo, R W Thomsen, J S Nielsen, S K Nicolaisen, H Beck-Nielsen, J Rungby, H T Sørensen, T K Hansen, J Søndergaard, S Friborg, T Lauritzen, H T Maindal

39 Citationer (Scopus)

Abstract

AIM: To examine the association between early onset of type 2 diabetes (DM) and clinical and behavioural risk factors for later diabetes complications.

METHODS: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early-onset) with diagnosis age 46-55, 56-65 (average-onset = reference), 66-75, and >75 years (late-onset). Prevalence ratios (PRs) were computed using Poisson regression.

RESULTS: Poor glucose control i.e. HbA1c≥75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1% respectively [PR 1.70 (95% confidence intervals (CI) 1.27, 2.28) and PR 0.17 (95% CI 0.06, 0.45)]. A similar age gradient was observed for severe obesity [BMI>40 kg/m(2) : 19% vs. 8% vs. 2%; PR 2.41 (95% CI 1.83, 3.18) and 0.21 (95% CI 0.08, 0.57)], dyslipidemia [90% vs. 79% vs. 68%; PR 1.14 (95% CI 1.10, 1.19) and 0.86 (95% CI 0.79, 0.93)], and low-grade inflammation [CRP>3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 (95% CI 1.12, 1.78) and 0.68 (95% CI 0.42, 1.11)]. Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM.

CONCLUSIONS: We found a clear age-gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.

OriginalsprogEngelsk
TidsskriftDiabetes - Metabolism: Research and Reviews (Online)
Vol/bind34
Udgave nummer3
Sider (fra-til)e2968
ISSN1520-7560
DOI
StatusUdgivet - mar. 2018

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