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Early onset type 2 diabetes: Age gradient in Clinical and Behavioural Risk Factors in 5115 Persons with Newly Diagnosed Type 2 Diabetes - Results from the DD2 study

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@article{e289d15c2e414ff0adf17cb606632797,
title = "Early onset type 2 diabetes: Age gradient in Clinical and Behavioural Risk Factors in 5115 Persons with Newly Diagnosed Type 2 Diabetes - Results from the DD2 study",
abstract = "AIM: To examine the association between early onset of type 2 diabetes (DM) and clinical and behavioural risk factors for later diabetes complications.METHODS: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early-onset) with diagnosis age 46-55, 56-65 (average-onset = reference), 66-75, and >75 years (late-onset). Prevalence ratios (PRs) were computed using Poisson regression.RESULTS: Poor glucose control i.e. HbA1c≥75 mmol/mol (≥9.0{\%}) in the early-, average-, and late-onset groups was observed in 12{\%}, 7{\%}, and 1{\%} respectively [PR 1.70 (95{\%} confidence intervals (CI) 1.27, 2.28) and PR 0.17 (95{\%} CI 0.06, 0.45)]. A similar age gradient was observed for severe obesity [BMI>40 kg/m(2) : 19{\%} vs. 8{\%} vs. 2{\%}; PR 2.41 (95{\%} CI 1.83, 3.18) and 0.21 (95{\%} CI 0.08, 0.57)], dyslipidemia [90{\%} vs. 79{\%} vs. 68{\%}; PR 1.14 (95{\%} CI 1.10, 1.19) and 0.86 (95{\%} CI 0.79, 0.93)], and low-grade inflammation [CRP>3.0 mg/L: 53{\%} vs. 38{\%} vs. 26{\%}; PR 1.41 (95{\%} CI 1.12, 1.78) and 0.68 (95{\%} CI 0.42, 1.11)]. Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM.CONCLUSIONS: We found a clear age-gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.",
keywords = "Journal Article",
author = "A Bo and Thomsen, {R W} and Nielsen, {J S} and Nicolaisen, {S K} and H Beck-Nielsen and J Rungby and S{\o}rensen, {H T} and Hansen, {T K} and J S{\o}ndergaard and S Friborg and T Lauritzen and Maindal, {H T}",
note = "This article is protected by copyright. All rights reserved.",
year = "2018",
month = "3",
doi = "10.1002/dmrr.2968",
language = "English",
volume = "34",
pages = "e2968",
journal = "Diabetes - Metabolism: Research and Reviews (Online)",
issn = "1520-7560",
publisher = "JohnWiley & Sons Ltd",
number = "3",

}

RIS

TY - JOUR

T1 - Early onset type 2 diabetes

T2 - Age gradient in Clinical and Behavioural Risk Factors in 5115 Persons with Newly Diagnosed Type 2 Diabetes - Results from the DD2 study

AU - Bo, A

AU - Thomsen, R W

AU - Nielsen, J S

AU - Nicolaisen, S K

AU - Beck-Nielsen, H

AU - Rungby, J

AU - Sørensen, H T

AU - Hansen, T K

AU - Søndergaard, J

AU - Friborg, S

AU - Lauritzen, T

AU - Maindal, H T

N1 - This article is protected by copyright. All rights reserved.

PY - 2018/3

Y1 - 2018/3

N2 - AIM: To examine the association between early onset of type 2 diabetes (DM) and clinical and behavioural risk factors for later diabetes complications.METHODS: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early-onset) with diagnosis age 46-55, 56-65 (average-onset = reference), 66-75, and >75 years (late-onset). Prevalence ratios (PRs) were computed using Poisson regression.RESULTS: Poor glucose control i.e. HbA1c≥75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1% respectively [PR 1.70 (95% confidence intervals (CI) 1.27, 2.28) and PR 0.17 (95% CI 0.06, 0.45)]. A similar age gradient was observed for severe obesity [BMI>40 kg/m(2) : 19% vs. 8% vs. 2%; PR 2.41 (95% CI 1.83, 3.18) and 0.21 (95% CI 0.08, 0.57)], dyslipidemia [90% vs. 79% vs. 68%; PR 1.14 (95% CI 1.10, 1.19) and 0.86 (95% CI 0.79, 0.93)], and low-grade inflammation [CRP>3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 (95% CI 1.12, 1.78) and 0.68 (95% CI 0.42, 1.11)]. Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM.CONCLUSIONS: We found a clear age-gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.

AB - AIM: To examine the association between early onset of type 2 diabetes (DM) and clinical and behavioural risk factors for later diabetes complications.METHODS: We conducted a cross-sectional study of 5115 persons with incident type 2 DM enrolled during 2010-2015 in the Danish Centre for Strategic Research in Type 2 Diabetes-cohort. We compared risk factors at time of diagnosis among those diagnosed at ≤45 years (early-onset) with diagnosis age 46-55, 56-65 (average-onset = reference), 66-75, and >75 years (late-onset). Prevalence ratios (PRs) were computed using Poisson regression.RESULTS: Poor glucose control i.e. HbA1c≥75 mmol/mol (≥9.0%) in the early-, average-, and late-onset groups was observed in 12%, 7%, and 1% respectively [PR 1.70 (95% confidence intervals (CI) 1.27, 2.28) and PR 0.17 (95% CI 0.06, 0.45)]. A similar age gradient was observed for severe obesity [BMI>40 kg/m(2) : 19% vs. 8% vs. 2%; PR 2.41 (95% CI 1.83, 3.18) and 0.21 (95% CI 0.08, 0.57)], dyslipidemia [90% vs. 79% vs. 68%; PR 1.14 (95% CI 1.10, 1.19) and 0.86 (95% CI 0.79, 0.93)], and low-grade inflammation [CRP>3.0 mg/L: 53% vs. 38% vs. 26%; PR 1.41 (95% CI 1.12, 1.78) and 0.68 (95% CI 0.42, 1.11)]. Daily smoking was more frequent and meeting physical activity recommendations less likely in persons with early-onset type 2 DM.CONCLUSIONS: We found a clear age-gradient, with increasing prevalence of clinical and behavioural risk factors the younger the onset age of type 2 DM. Younger persons with early-onset type 2 DM need clinical awareness and support.

KW - Journal Article

U2 - 10.1002/dmrr.2968

DO - 10.1002/dmrr.2968

M3 - Journal article

VL - 34

SP - e2968

JO - Diabetes - Metabolism: Research and Reviews (Online)

JF - Diabetes - Metabolism: Research and Reviews (Online)

SN - 1520-7560

IS - 3

ER -

ID: 52062960