Early nasal continuous positive airway pressure in a cohort of the smallest infants in Denmark: Neurodevelopmental outcome at five years of age

B. M. Hansen*, B. Hoff, G. Greisen, E. L. Mortensen

*Corresponding author af dette arbejde
35 Citationer (Scopus)

Abstract

AIM: To evaluate neurodevelopmental outcome at age 5 y of age in a cohort of preterm children treated mainly with nasal continuous positive airway pressure (CPAP) in the neonatal period.

METHODS: A national prospective observational study was conducted in Denmark which included all 269 surviving children with a birthweight below 1000 g or a gestational age below 28 wk born in Denmark in between 1994 and 1995. A total of 164 children (61%) had been treated with nasal CPAP only in the neonatal period. A reference group (n = 76) of term children was studied in parallel.

RESULTS: Of the 269 surviving children, 252 (94%) were examined. Twenty-four children (10%) had cerebral palsy, and three children were blind. No case of hearing impairment was detected. Nineteen percent of the index children had an IQ score <-- 2 SD and 42% had an IQ score <-- 1 SD of the mean score of the reference group.

CONCLUSIONS: The intellectual development of children in this cohort treated with early nasal CPAP did not suggest a higher proportion of adverse effects on the brain compared to the published follow-up studies of preterm children treated with mechanical ventilation. In our population-based cohort, however, the survival rate for infants below 25 wk of gestation was relatively low and this may indicate a limit for the use of early nasal CPAP.

OriginalsprogEngelsk
TidsskriftActa Paediatrica, International Journal of Paediatrics
Vol/bind93
Udgave nummer2
Sider (fra-til)190-195
Antal sider6
ISSN0803-5253
DOI
StatusUdgivet - feb. 2004

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