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Early Life Body Size in Relation to First Intracerebral or Subarachnoid Hemorrhage

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Dokumenter

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  1. Risk of Ischemic and Hemorrhagic Strokes in Occult and Manifest Cancers

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Alcohol Intake and Risk of Ischemic and Haemorrhagic Stroke: Results from a Mendelian Randomisation Study

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  3. Childhood Stature and Growth in Relation to First Ischemic Stroke or Intracerebral Hemorrhage

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Neuroregeneration and Vascular Protection by Citalopram in Acute Ischemic Stroke (TALOS)

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  1. Levels of and Changes in Childhood Body Mass Index in Relation to Risk of Atrial Fibrillation and Atrial Flutter in Adulthood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Changes in Childhood Body-Mass Index and Risk of Venous Thromboembolism in Adulthood

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Childhood overweight, tallness and growth increase risks of ovarian cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Global, Regional, and Country-Specific Lifetime Risks of Stroke, 1990 and 2016

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background and Purpose: As risk of hemorrhagic stroke may have early life origins, we investigated associations of birth weight and childhood body mass index (BMI) with adult intracerebral hemorrhage (ICH) or subarachnoid hemorrhage (SAH).

Methods: We included 240,234 Danish schoolchildren, born 1936 to 1989, with information on birth weight and measured weights and heights from 7 to 13 years. We calculated hazard ratios (HRs) and confidence intervals (CIs) for the associations between early life anthropometrics and ICH or SAH, identified through linkage with national registers.

Results: During the study period, 1,947 individuals (39% women) experienced an ICH and 797 individuals (64% women) experienced a SAH. Per 500 g increase in birth weight, women had a 10% decreased risk of SAH (HR, 0.90; 95% CI, 0.83 to 0.97) and men had a 10% decreased risk of ICH (HR, 0.90; 95% CI, 0.85 to 0.95). Birth weight was not associated with risks of ICH in women or SAH in men. In men, a childhood BMI below average (BMI z-score <0) was associated with increased risks of ICH. The association was stronger at older childhood ages, and at 13 years a BMI z-score of -1 was associated with a HR of 1.17 (95% CI, 1.06 to 1.28), and a BMI z-score of -2 with a HR of 1.46 (95% CI, 1.17 to 1.82) for ICH. Childhood BMI was not associated with risks of ICH in women or with risks of SAH in both sexes.

Conclusions: Early life body size is associated with ICH and SAH, and the associations differ by sex.

OriginalsprogEngelsk
TidsskriftStroke
Vol/bind21
Udgave nummer1
Sider (fra-til)60-68
Antal sider9
ISSN2287-6391
DOI
StatusUdgivet - jan. 2019

ID: 56106289