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Region Hovedstaden - en del af Københavns Universitetshospital
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Early life body size and its associations with adult bladder cancer

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

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  3. Changes in body water distribution during treatment with inhaled steroid in pre-school children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Birth weight, childhood body mass index and height and risks of endometriosis and adenomyosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Early life body size in relation to risk of renal cell carcinoma in adulthood: a Danish observational cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Leptin, adiponectin, and their ratio as markers of insulin resistance and cardiometabolic risk in childhood obesity

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  4. Change in body mass index from childhood onwards and risk of adult cardiovascular disease

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Vis graf over relationer

Background: Adult overweight is a potential bladder cancer (BC) risk factor, but little is known about size earlier in life.Aim: To investigate if birth weight, childhood body mass index (BMI), height and growth are associated with adult BC.Subjects and methods: Anthropometric information from birth and ages 7-13 on 315,763 individuals born 1930-1989 in the Copenhagen School Health Records Register was linked to national registers. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated by Cox regression.Results: 1145 individuals (839 men) were diagnosed with BC. Sex differences were not detected. Childhood BMI had positive associations and height had inverse associations with BC; at age 13, HR = 1.10 (95% CI: 1.02-1.18) per BMI z-score and HR = 0.94 (95% CI: 0.89-1.00) per height z-score. A pattern of above-average increases in BMI from 7 to 13 years had higher hazards of BC than average increases. Above-average growth in height was not significantly associated with BC. Compared with birth weights of 3.5 kg, low (2.5 kg) and high (4.5 kg) values were associated with increased hazards of BC; HR = 1.26 (95% CI: 1.01-1.58) and HR = 1.36 (95% CI: 1.09-1.70), respectively.Conclusions: A high BMI, a short height, excess BMI gain in childhood and low and high birth weights are associated with increased hazards of BC.

OriginalsprogEngelsk
TidsskriftAnnals of Human Biology
Vol/bind47
Udgave nummer2
Sider (fra-til)166-172
Antal sider7
ISSN0301-4460
DOI
StatusUdgivet - mar. 2020

ID: 60053550