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Early life bacterial airway colonization, local immune mediator response and risk of otitis media

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@article{4469e5ddea9e4ac4934a7fadc932c8de,
title = "Early life bacterial airway colonization, local immune mediator response and risk of otitis media",
abstract = "Introduction. Acute otitis media (AOM) is the most common bacterial infection in early childhood, but the underlying mechanisms making some children more susceptible are poorly understood.Aim. To examine the associations between bacterial airway colonization in early life and the risk of AOM and tympanostomy tube insertion (TTI), and whether such associations are modulated by an insufficient local immune mediator response to bacterial colonization.Methodology. Bacterial cultures from hypopharyngeal samples were obtained at 1 week, 1 month and 3 months of age in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising 700 children. Twenty immune mediators were quantified from airway mucosal lining fluid sampled at 1 month. AOM symptoms were registered in a daily diary until 3 years. Information on TTI in the first 3 years was obtained from national registers.Results. Children colonized with Streptococcus pneumoniae at 1 month of age had increased incidence of AOM [aIRR 2.43 (1.14-5.21)] and children colonized with Moraxella catarrhalis at 1 month or Haemophilus influenzae at 3 months had an increased risk of TTI [aHR 1.45 (1.00-2.10) and 1.73 (1.10-2.71)]. There were no associations between the local immune mediator response to colonization and risk of AOM or TTI.Conclusion. Pathogenic bacterial airway colonization in early life was found to be associated with an increased risk of otitis media, albeit not consistently. These associations were independent of the local immune response to colonization.",
keywords = "Analysis of Variance, Chi-Square Distribution, Child, Preschool, Humans, Infant, Infant, Newborn, Linear Models, Otitis Media/epidemiology, Poisson Distribution, Principal Component Analysis, Proportional Hazards Models, Respiratory System/immunology, Risk Factors, Statistics, Nonparametric",
author = "Christensen, {Emil Dalgaard} and Jonathan Thorsen and Jakob Stokholm and Pedersen, {Tine Marie} and Susanne Brix and Krogfelt, {Karen Angeliki} and Susanne Schj{\o}rring and Bo Chawes and Klaus B{\o}nnelykke and Hans Bisgaard and Rasmussen, {Morten Arendt}",
year = "2020",
month = aug,
doi = "10.1099/jmm.0.001227",
language = "English",
volume = "69",
pages = "1124--1131",
journal = "Journal of Medical Microbiology",
issn = "0022-2615",
publisher = "Society for General Microbiology",
number = "8",

}

RIS

TY - JOUR

T1 - Early life bacterial airway colonization, local immune mediator response and risk of otitis media

AU - Christensen, Emil Dalgaard

AU - Thorsen, Jonathan

AU - Stokholm, Jakob

AU - Pedersen, Tine Marie

AU - Brix, Susanne

AU - Krogfelt, Karen Angeliki

AU - Schjørring, Susanne

AU - Chawes, Bo

AU - Bønnelykke, Klaus

AU - Bisgaard, Hans

AU - Rasmussen, Morten Arendt

PY - 2020/8

Y1 - 2020/8

N2 - Introduction. Acute otitis media (AOM) is the most common bacterial infection in early childhood, but the underlying mechanisms making some children more susceptible are poorly understood.Aim. To examine the associations between bacterial airway colonization in early life and the risk of AOM and tympanostomy tube insertion (TTI), and whether such associations are modulated by an insufficient local immune mediator response to bacterial colonization.Methodology. Bacterial cultures from hypopharyngeal samples were obtained at 1 week, 1 month and 3 months of age in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising 700 children. Twenty immune mediators were quantified from airway mucosal lining fluid sampled at 1 month. AOM symptoms were registered in a daily diary until 3 years. Information on TTI in the first 3 years was obtained from national registers.Results. Children colonized with Streptococcus pneumoniae at 1 month of age had increased incidence of AOM [aIRR 2.43 (1.14-5.21)] and children colonized with Moraxella catarrhalis at 1 month or Haemophilus influenzae at 3 months had an increased risk of TTI [aHR 1.45 (1.00-2.10) and 1.73 (1.10-2.71)]. There were no associations between the local immune mediator response to colonization and risk of AOM or TTI.Conclusion. Pathogenic bacterial airway colonization in early life was found to be associated with an increased risk of otitis media, albeit not consistently. These associations were independent of the local immune response to colonization.

AB - Introduction. Acute otitis media (AOM) is the most common bacterial infection in early childhood, but the underlying mechanisms making some children more susceptible are poorly understood.Aim. To examine the associations between bacterial airway colonization in early life and the risk of AOM and tympanostomy tube insertion (TTI), and whether such associations are modulated by an insufficient local immune mediator response to bacterial colonization.Methodology. Bacterial cultures from hypopharyngeal samples were obtained at 1 week, 1 month and 3 months of age in the Copenhagen Prospective Studies on Asthma in Childhood 2010 (COPSAC2010) cohort comprising 700 children. Twenty immune mediators were quantified from airway mucosal lining fluid sampled at 1 month. AOM symptoms were registered in a daily diary until 3 years. Information on TTI in the first 3 years was obtained from national registers.Results. Children colonized with Streptococcus pneumoniae at 1 month of age had increased incidence of AOM [aIRR 2.43 (1.14-5.21)] and children colonized with Moraxella catarrhalis at 1 month or Haemophilus influenzae at 3 months had an increased risk of TTI [aHR 1.45 (1.00-2.10) and 1.73 (1.10-2.71)]. There were no associations between the local immune mediator response to colonization and risk of AOM or TTI.Conclusion. Pathogenic bacterial airway colonization in early life was found to be associated with an increased risk of otitis media, albeit not consistently. These associations were independent of the local immune response to colonization.

KW - Analysis of Variance

KW - Chi-Square Distribution

KW - Child, Preschool

KW - Humans

KW - Infant

KW - Infant, Newborn

KW - Linear Models

KW - Otitis Media/epidemiology

KW - Poisson Distribution

KW - Principal Component Analysis

KW - Proportional Hazards Models

KW - Respiratory System/immunology

KW - Risk Factors

KW - Statistics, Nonparametric

U2 - 10.1099/jmm.0.001227

DO - 10.1099/jmm.0.001227

M3 - Journal article

C2 - 32597749

VL - 69

SP - 1124

EP - 1131

JO - Journal of Medical Microbiology

JF - Journal of Medical Microbiology

SN - 0022-2615

IS - 8

ER -

ID: 61276491