Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study

Line Kessel; Torben Jørgensen; Charlotte Glümer; Michael Larsen

doi:10.1186/1471-2415-6-16

Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study

Line Kessel, Torben Jørgensen, Charlotte Glümer, Michael Larsen

Abstract

BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging.

METHODS: A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard software. Lens aging was quantified by lens fluorometry.

RESULTS: The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia.

CONCLUSION: The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.

Originalsprog	Engelsk
Tidsskrift	BMC Ophthalmology
Vol/bind	6
Sider (fra-til)	16
ISSN	1471-2415
DOI	https://doi.org/10.1186/1471-2415-6-16
Status	Udgivet - 18 apr. 2006
Udgivet eksternt	Ja

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10.1186/1471-2415-6-16

Citationsformater

@article{96f66b0832974f18940a4ba3093bc32d,

title = "Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study",

abstract = "BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging.METHODS: A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard software. Lens aging was quantified by lens fluorometry.RESULTS: The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia.CONCLUSION: The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.",

keywords = "Adult, Diabetes Complications, Female, Fluorescence, Fluorophotometry, Humans, Lens, Crystalline/metabolism, Male, Middle Aged, Myocardial Ischemia/etiology, Risk Assessment/methods, Risk Factors, Smoking/adverse effects",

author = "Line Kessel and Torben J{\o}rgensen and Charlotte Gl{\"u}mer and Michael Larsen",

year = "2006",

month = apr,

day = "18",

doi = "10.1186/1471-2415-6-16",

language = "English",

volume = "6",

pages = "16",

journal = "BMC Ophthalmology",

issn = "1471-2415",

publisher = "BioMed Central Ltd",

}

TY - JOUR

T1 - Early lens aging is accelerated in subjects with a high risk of ischemic heart disease

T2 - an epidemiologic study

AU - Kessel, Line

AU - Jørgensen, Torben

AU - Glümer, Charlotte

AU - Larsen, Michael

PY - 2006/4/18

Y1 - 2006/4/18

N2 - BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging.METHODS: A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard software. Lens aging was quantified by lens fluorometry.RESULTS: The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia.CONCLUSION: The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.

AB - BACKGROUND: Ischemic heart disease (IHD) is one of the most important causes of mortality and morbidity in the Western world. There is a relationship between aging of the lens of the human eye and cardiovascular disease. The present study was conducted to examine if the risk of ischemic heart disease could be estimated by fluorophotometric assessment of lens aging.METHODS: A total of 421 subjects were included. Risk of IHD was estimated from non-ocular data using the Precard software. Lens aging was quantified by lens fluorometry.RESULTS: The risk of IHD was strongly related to lens fluorophore accumulation (p = 0.001). The relationship between IHD and lens aging was attributable to tobacco smoking and dysglycemia.CONCLUSION: The risk of ischemic heart disease related to smoking and diabetes mellitus can be estimated using the aging of the lens of the eye as a biomarker for generalized tissue-damage.

KW - Adult

KW - Diabetes Complications

KW - Female

KW - Fluorescence

KW - Fluorophotometry

KW - Humans

KW - Lens, Crystalline/metabolism

KW - Male

KW - Middle Aged

KW - Myocardial Ischemia/etiology

KW - Risk Assessment/methods

KW - Risk Factors

KW - Smoking/adverse effects

U2 - 10.1186/1471-2415-6-16

DO - 10.1186/1471-2415-6-16

M3 - Journal article

C2 - 16618373

SN - 1471-2415

VL - 6

SP - 16

JO - BMC Ophthalmology

JF - BMC Ophthalmology

ER -

Early lens aging is accelerated in subjects with a high risk of ischemic heart disease: an epidemiologic study

Abstract

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