Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Early Intrathecal T Helper 17.1 Cell Activity in Huntington Disease

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Genetic Susceptibility Loci in Genomewide Association Study of Cluster Headache

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Amylin Analog Pramlintide Induces Migraine-like Attacks in Patients

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. MRI in Neuromuscular Diseases: An Emerging Diagnostic Tool and Biomarker for Prognosis and Efficacy

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Optic Disc Classification by Deep Learning versus Expert Neuro-Ophthalmologists

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A New Glycogen Storage Disease Caused by a Dominant PYGM Mutation

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Dimethyl Fumarate Treatment in Patients With Primary Progressive Multiple Sclerosis: A Randomized, Controlled Trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Endophenotypical drift in Huntington's disease: a 5-year follow-up study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

OBJECTIVE: Huntington disease (HD) is an autosomal dominantly inherited neurodegenerative disorder caused by a CAG repeat expansion in the huntingtin (HTT) gene. No disease-modifying therapy exists for the treatment of patients with HD. The purpose of this study was therefore to investigate early disease mechanisms that potentially could be used as a target therapeutically.

METHODS: Lymphocyte activity in cerebrospinal fluid (CSF) from 4 cohorts of HTT gene expansion carriers (n = 121 in total) and controls was analyzed by techniques based on flow cytometry and enzyme-linked immunosorbent assays.

RESULTS: The data of this study provide evidence of immune abnormalities before motor onset of disease. In CSF of HTT gene expansion carriers, we found increased levels of proinflammatory cytokines, including IL-17, and increased consumption of the lymphocyte growth factor IL-7 before motor onset of HD. In concordance, we observed an increased prevalence of IL-17-producing Th17.1 cells in the CSF of HTT gene expansion carriers, predominantly in pre-motor manifest individuals. The frequency of intrathecal Th17.1 cells correlated negatively with progression of HD and the level of neurodegeneration, suggesting a role of Th17.1 cells in the early disease stage. We also observed a skewing in the balance between proinflammatory and regulatory T cells potentially favoring a proinflammatory intrathecal environment in HTT gene expansion carriers.

INTERPRETATION: These data suggest that Th17.1 cells are implicated in the earliest pathogenic phases of HD and suggest that treatment to dampen T -cell-driven inflammation before motor onset might be of benefit in HTT gene expansion carriers. ANN NEUROL 2019.

OriginalsprogEngelsk
TidsskriftAnnals of Neurology
Vol/bind87
Udgave nummer2
Sider (fra-til)246-255
Antal sider10
ISSN0364-5134
DOI
StatusUdgivet - 1 feb. 2020

Bibliografisk note

© 2019 American Neurological Association.

ID: 58652565