Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital

Early, integrated palliative rehabilitation improves quality of life of patients with newly diagnosed advanced cancer: The Pal-Rehab randomized controlled trial

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review


  1. Early specialised palliative care: interventions, symptoms, problems

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Investigating the response scale of the EORTC QLQ-C30 in German cancer patients and a population survey

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Minimally important differences for the EORTC QLQ-C30 in prostate cancer clinical trials

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Size and composition of family networks of decedents: A nationwide register-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: Early integration of palliative care into oncology treatment is widely recommended. Palliative rehabilitation has been suggested as a paradigm which integrates enablement, self-management, and self-care into the holistic model of palliative care.

AIM: We hypothesized that early integration of palliative rehabilitation could improve quality of life.

DESIGN: The Pal-Rehab study ( NCT02332317) was a randomized controlled trial. The 12-week intervention offered by a specialized palliative care team was two mandatory consultations and the opportunity of participating in an interdisciplinary group program. Supplementary individual consultations were offered, if needed.

SETTING/PARTICIPANTS: At Vejle University Hospital, Denmark, adults diagnosed with advanced cancer within the last 8 weeks were randomized 1:1 to standard oncology care or standard care plus intervention. Assessments at baseline and after six and 12 weeks were based on the European Organization for Research and Treatment of Cancer Quality of Life Core Questionnaire (EORTC QLQ-C30). At baseline participants were asked to choose a "primary problem" from a list of QLQ-C30 domains. The primary endpoint was the change in that "primary problem" measured as area under the curve across 12 weeks (T-scores, European mean value = 50, SD = 10).

RESULTS: In all, 288 were randomized of whom 279 were included in the modified intention-to-treat analysis (146 in the standard care group and 133 in the intervention group). The between-group difference for the primary outcome was 3.0 (95% CI [0.0-6.0]; p = 0.047) favoring the intervention.

CONCLUSION: Early integration of palliative rehabilitation into standard oncology treatment improved quality of life for newly diagnosed advanced cancer patients.

TRIAL REGISTRATION: Identifier: NCT02332317, registered on December 30, 2014.

TidsskriftPalliative Medicine
Udgave nummer7
Sider (fra-til)1344-1355
Antal sider12
StatusUdgivet - jul. 2021

ID: 67449312