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Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer: secondary outcomes from a randomized trial

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@article{04a3e6557c8548278773cc5a75859ef8,
title = "Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer: secondary outcomes from a randomized trial",
abstract = "Introduction: Patients with lung cancer report a lower degree of Health Related Quality of Life (HRQoL) compared with other cancer patients. HRQoL reflects how patients experience the impact of their disease and its treatment on their quality of daily living. A widely used questionnaire in lung cancer patients is the Functional Assessment of Cancer Therapy – Lung (FACT-L) questionnaire. Here we report the secondary outcomes on FACT-L data from the Postoperative Rehabilitation in Operation for Lung CAncer (PROLUCA) study, which describes the effect of early (14 days) versus late initiated (14 weeks) postoperative rehabilitation. Materials and methods: The PROLUCA study was designed as a two-armed randomized controlled trial with an early rehabilitation group (14 days after surgery (ERG)) or a control arm with a late rehabilitation group (14 weeks after surgery (LRG)). The results for seven domain scores obtained using the FACT-L at the following time-points: baseline, 14 weeks, 26 weeks and 52 weeks after surgery are presented here. Results: 119 patients were randomized to the ERG and 116 to the LRG. In the ERG, HRQoL measured by both FACT-L and FACT-G (general core instrument) showed a continuous improvement up to 26 weeks after which HRQoL decreased after further 26 weeks without structured intervention. In the LRG a non-significant deterioration was detected over the first 14 weeks after surgery. After participation in the 12 weeks rehabilitation program, an increase in HRQoL was seen, without reaching the same level as the early group. Conclusion: Analyses of the seven domain scores obtained using FACT-L and FACT-G reflect the importance of starting exercise early after surgery since the ERG avoid a temporary decrease in HRQoL. It is therefore recommended to start up a structured rehabilitation program 14 days after surgery, containing high intensity interval training and strength exercise twice a week for 12 weeks.",
keywords = "Functional assessment of cancer therapy, Health related quality of life, Lung cancer, Postoperative exercise, Rehabilitation",
author = "Sommer, {Maja Schick} and Jette Vibe-Petersen and St{\ae}rkind, {Maja Bohlbro} and Langer, {Seppo W.} and Larsen, {Klaus Richter} and Karen Trier and Merete Christensen and Clementsen, {Paul F.} and Malene Missel and Christensen, {Karl Bang} and Christian Lillelund and Henning Langberg and Pedersen, {Jesper H.} and Morten Quist",
note = "Funding Information: The present study was supported by grants from the Center for Integrated Rehabilitation of Cancer patients ( CIRE ), which was established and supported by the Danish Cancer Society and the Novo Nordic Foundation. Publisher Copyright: {\textcopyright} 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
month = aug,
doi = "10.1016/j.lungcan.2020.06.023",
language = "English",
volume = "146",
pages = "285--289",
journal = "Lung Cancer",
issn = "0169-5002",
publisher = "Elsevier Ireland Ltd",

}

RIS

TY - JOUR

T1 - Early initiated postoperative rehabilitation enhances quality of life in patients with operable lung cancer

T2 - secondary outcomes from a randomized trial

AU - Sommer, Maja Schick

AU - Vibe-Petersen, Jette

AU - Stærkind, Maja Bohlbro

AU - Langer, Seppo W.

AU - Larsen, Klaus Richter

AU - Trier, Karen

AU - Christensen, Merete

AU - Clementsen, Paul F.

AU - Missel, Malene

AU - Christensen, Karl Bang

AU - Lillelund, Christian

AU - Langberg, Henning

AU - Pedersen, Jesper H.

AU - Quist, Morten

N1 - Funding Information: The present study was supported by grants from the Center for Integrated Rehabilitation of Cancer patients ( CIRE ), which was established and supported by the Danish Cancer Society and the Novo Nordic Foundation. Publisher Copyright: © 2020 Copyright: Copyright 2020 Elsevier B.V., All rights reserved.

PY - 2020/8

Y1 - 2020/8

N2 - Introduction: Patients with lung cancer report a lower degree of Health Related Quality of Life (HRQoL) compared with other cancer patients. HRQoL reflects how patients experience the impact of their disease and its treatment on their quality of daily living. A widely used questionnaire in lung cancer patients is the Functional Assessment of Cancer Therapy – Lung (FACT-L) questionnaire. Here we report the secondary outcomes on FACT-L data from the Postoperative Rehabilitation in Operation for Lung CAncer (PROLUCA) study, which describes the effect of early (14 days) versus late initiated (14 weeks) postoperative rehabilitation. Materials and methods: The PROLUCA study was designed as a two-armed randomized controlled trial with an early rehabilitation group (14 days after surgery (ERG)) or a control arm with a late rehabilitation group (14 weeks after surgery (LRG)). The results for seven domain scores obtained using the FACT-L at the following time-points: baseline, 14 weeks, 26 weeks and 52 weeks after surgery are presented here. Results: 119 patients were randomized to the ERG and 116 to the LRG. In the ERG, HRQoL measured by both FACT-L and FACT-G (general core instrument) showed a continuous improvement up to 26 weeks after which HRQoL decreased after further 26 weeks without structured intervention. In the LRG a non-significant deterioration was detected over the first 14 weeks after surgery. After participation in the 12 weeks rehabilitation program, an increase in HRQoL was seen, without reaching the same level as the early group. Conclusion: Analyses of the seven domain scores obtained using FACT-L and FACT-G reflect the importance of starting exercise early after surgery since the ERG avoid a temporary decrease in HRQoL. It is therefore recommended to start up a structured rehabilitation program 14 days after surgery, containing high intensity interval training and strength exercise twice a week for 12 weeks.

AB - Introduction: Patients with lung cancer report a lower degree of Health Related Quality of Life (HRQoL) compared with other cancer patients. HRQoL reflects how patients experience the impact of their disease and its treatment on their quality of daily living. A widely used questionnaire in lung cancer patients is the Functional Assessment of Cancer Therapy – Lung (FACT-L) questionnaire. Here we report the secondary outcomes on FACT-L data from the Postoperative Rehabilitation in Operation for Lung CAncer (PROLUCA) study, which describes the effect of early (14 days) versus late initiated (14 weeks) postoperative rehabilitation. Materials and methods: The PROLUCA study was designed as a two-armed randomized controlled trial with an early rehabilitation group (14 days after surgery (ERG)) or a control arm with a late rehabilitation group (14 weeks after surgery (LRG)). The results for seven domain scores obtained using the FACT-L at the following time-points: baseline, 14 weeks, 26 weeks and 52 weeks after surgery are presented here. Results: 119 patients were randomized to the ERG and 116 to the LRG. In the ERG, HRQoL measured by both FACT-L and FACT-G (general core instrument) showed a continuous improvement up to 26 weeks after which HRQoL decreased after further 26 weeks without structured intervention. In the LRG a non-significant deterioration was detected over the first 14 weeks after surgery. After participation in the 12 weeks rehabilitation program, an increase in HRQoL was seen, without reaching the same level as the early group. Conclusion: Analyses of the seven domain scores obtained using FACT-L and FACT-G reflect the importance of starting exercise early after surgery since the ERG avoid a temporary decrease in HRQoL. It is therefore recommended to start up a structured rehabilitation program 14 days after surgery, containing high intensity interval training and strength exercise twice a week for 12 weeks.

KW - Functional assessment of cancer therapy

KW - Health related quality of life

KW - Lung cancer

KW - Postoperative exercise

KW - Rehabilitation

UR - http://www.scopus.com/inward/record.url?scp=85086872010&partnerID=8YFLogxK

U2 - 10.1016/j.lungcan.2020.06.023

DO - 10.1016/j.lungcan.2020.06.023

M3 - Journal article

C2 - 32593918

AN - SCOPUS:85086872010

VL - 146

SP - 285

EP - 289

JO - Lung Cancer

JF - Lung Cancer

SN - 0169-5002

ER -

ID: 60188703