Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Early indicators of primary brain tumours: a population-based study with 10 years’ follow-up

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. A European Academy of Neurology guideline on medical management issues in dementia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Deep phenotyping of facioscapulohumeral muscular dystrophy type 2 by magnetic resonance imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. EAN/ERS/ESO/ESRS statement on the impact of sleep disorders on risk and outcome of stroke

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. European Academy of Neurology guideline on the diagnosis of coma and other disorders of consciousness

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. A population-based epidemiological study of neuromyelitis optica spectrum disorder in Hungary

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Gynaecological cancer leads to long-term sick leave and permanently reduced working ability years after diagnosis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Development of sarcopenia in patients with bladder cancer: A systematic review Seminars

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Patterns in detection of recurrence among patients treated for breast cancer

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Antidepressant Use in Siblings of Children With Cancer: A Danish Population-Based Cohort Study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Background and purpose: To improve diagnoses of primary brain tumours, knowledge about early indicators is needed. Nationwide Danish health registries were used to conduct a population-based case–control study including all persons diagnosed with a primary brain tumour between 2005 and 2014 in Denmark. Methods: All 5135 adults diagnosed with a primary brain tumour in the Danish Cancer Registry were matched to 19 572 general population comparisons from the Danish Civil Registration System. Conditional logistic regression analyses were applied to estimate age- and multivariable-adjusted odds ratios (ORs) for the occurrence of a primary brain tumour up to 10 years after hospital diagnoses or prescription of medications related to nervous system diseases and mental and behavioural disorders. Results: Increased odds for primary brain tumour after nervous system diseases and mental and behavioural disorders manifested up to 10 years before tumour diagnosis were found. Increased odds were seen especially for hospital contacts for inflammatory nervous system diseases [OR 11.3; 95% confidence interval (CI) 6.5–19.7], epilepsy (OR 9.0; 95% CI 7.6–10.7) and antiepileptic medications (OR 3.6; 95% CI 3.2–4.0), whilst antidementia medications provided a strong, protective association for primary brain tumours (OR 0.5; 95% CI 0.3–0.8). Conclusions: Sub-groups of patients diagnosed with or being prescribed certain medications targeting nervous system diseases and mental and behavioural disorders may be at increased risk of being diagnosed with a primary brain tumour. Further studies should disentangle the potential underlying common pathogenetic pathways. The results are important for the development of systematic clinical approaches to ensure early diagnosis of primary brain tumours.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
Vol/bind28
Udgave nummer1
Sider (fra-til)278-285
Antal sider8
ISSN1351-5101
DOI
StatusUdgivet - jan. 2021

ID: 60964639