Early detection of colorectal neoplasia: application of a blood-based serological protein test on subjects undergoing population-based screening

Jakob Kleif, Lars Nannestad Jørgensen, Jakob W Hendel, Mogens R Madsen, Jesper Vilandt, Søren Brandsborg, Lars Maagaard Andersen, Ali Khalid, Peter Ingeholm, Linnea Ferm, Gerard J Davis, Susan H Gawel, Frans Martens, Berit Andersen, Morten Rasmussen, Ib Jarle Christensen, Hans Jørgen Nielsen

2 Citationer (Scopus)

Abstract

BACKGROUND: Blood-based biomarkers used for colorectal cancer screening need to be developed and validated in appropriate screening populations. We aimed to develop a cancer-associated protein biomarker test for the detection of colorectal cancer in a screening population.

METHODS: Participants from the Danish Colorectal Cancer Screening Program were recruited. Blood samples were collected prior to colonoscopy. The cohort was divided into training and validation sets. We present the results of model development using the training set. Age, sex, and the serological proteins CEA, hsCRP, TIMP-1, Pepsinogen-2, HE4, CyFra21-1, Galectin-3, ferritin and B2M were used to develop a signature test to discriminate between participants with colorectal cancer versus all other findings at colonoscopy.

RESULTS: The training set included 4048 FIT-positive participants of whom 242 had a colorectal cancer. The final model for discriminating colorectal cancer versus all other findings at colonoscopy had an AUC of 0.70 (95% CI: 0.66-0.74) and included age, sex, CEA, hsCRP, HE4 and ferritin.

CONCLUSION: The performance of the biomarker signature in this FIT-positive screening population did not reflect the positive performance of biomarker signatures seen in symptomatic populations. Additional biomarkers are needed if the serological biomarkers are to be used as a frontline screening test.

OriginalsprogEngelsk
TidsskriftBritish Journal of Cancer
Vol/bind126
Udgave nummer10
Sider (fra-til)1387-1393
Antal sider7
ISSN0007-0920
DOI
StatusUdgivet - jun. 2022

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