Early autologous blood pleurodesis for postoperative air leaks: A randomized, controlled trial comparing prophylactic autologous blood pleurodesis versus standard watch and wait treatment for postoperative air leaks following thoracoscopic (VATS) anatomic lung resections

Loannis Karampinis*, Christian Ruckes, Fabian Doerr, Servet Boeluekbas, Sara Ricciardi, Giuseppe Cardillo, Carlos Galvez, Bogdan Vidmar, Tomaž Štupnik, Vincent Fang, Rene Horsleben Petersen, Eric Dominic Roessner

*Corresponding author af dette arbejde

Abstract

Background: The prolonged air leak is probably the most common complication following lung resections. Around 10-20% of the patients that undergo a lung resection will eventually develop a
prolonged air leak. The definition of a prolonged air leak varies between an air leak, which is evident after the fifth, seven or even tenth postoperative day to every air leak that prolongs the hospital stay. However, the postoperative hospital stay following a thoracoscopic lobectomy can be as short as two days, making the above definitions sound outdated. The treatment of these air leaks is also very versatile. One of the broadly accepted treatment options is the autologous blood pleurodesis or “blood patch”. The
purpose of this trial is to investigate the impact of a prophylactic autologous blood pleurodesis on reducing the duration of the postoperative air leak and therefore prevent the air leak from becoming prolonged.
Methods: Patients undergoing an elective thoracoscopic anatomic lung resection for primary lung cancer or metastatic disease will be eligible for recruitment. Patients with an air leak of > 100ml/min within 6 hours prior to the morning round on the second postoperative day will be eligible for inclusion in
the study and randomization. Patients will be randomized to either blood pleurodesis or watchful waiting.Primary endpoint is the time to drain removal measured in full days. The trial ends on the seventh postoperative day.
Discussion: The early autologous blood pleurodesis could lead to a faster cessation of the air leak and therefore to a faster removal of the drain. A faster removal of the drain would relieve the patient from all the well-known drain associated complications (longer hospital stay, stronger postoperative pain, risk of drain-associated infection etc.). From the economical point of view, faster drain removal would reduce the hospital costs as well as the costs associated with the care of a patient with a chest drain on an
outpatient setting.
OriginalsprogEngelsk
TidsskriftResearch Square
Sider (fra-til)1-20
Antal sider20
DOI
StatusUdgivet - 2023

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