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EAACI Molecular Allergology User's Guide

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Perioperative anaphylaxis in children: Etiology, time sequence, and patterns of clinical reactivity

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Single and multiple time-point allergic sensitization during childhood and risk of asthma by age 13

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Neonatal BCG has no effect on allergic sensitization and suspected food allergy until 13 months

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The validity of register data to identify children with atopic dermatitis, asthma or allergic rhinoconjunctivitis

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Neonatal risk factors of atopic dermatitis in Denmark - Results from a nationwide register-based study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Allergy Development in Adulthood: An Occupational Cohort Study of the Manufacturing of Industrial Enzymes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Identifying and managing patients at risk of severe allergic reactions to food: Report from two iFAAM workshops

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Rational Design, Structure-Activity Relationship, and Immunogenicity of Hypoallergenic Pru p 3 Variants

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. The Clinical Relevance of Natural Rubber Latex-Specific IgE in Patients Sensitized to Timothy Grass Pollen

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • P M Matricardi
  • J Kleine-Tebbe
  • H J Hoffmann
  • R Valenta
  • C Hilger
  • S Hofmaier
  • R C Aalberse
  • I Agache
  • R Asero
  • B Ballmer-Weber
  • D Barber
  • K Beyer
  • T Biedermann
  • M B Bilò
  • S Blank
  • B Bohle
  • P P Bosshard
  • H Breiteneder
  • H A Brough
  • L Caraballo
  • J C Caubet
  • R Crameri
  • J M Davies
  • N Douladiris
  • M Ebisawa
  • P A EIgenmann
  • M Fernandez-Rivas
  • F Ferreira
  • G Gadermaier
  • M Glatz
  • R G Hamilton
  • T Hawranek
  • P Hellings
  • K Hoffmann-Sommergruber
  • T Jakob
  • U Jappe
  • M Jutel
  • S D Kamath
  • E F Knol
  • P Korosec
  • A Kuehn
  • G Lack
  • A L Lopata
  • M Mäkelä
  • M Morisset
  • V Niederberger
  • A H Nowak-Węgrzyn
  • N G Papadopoulos
  • E A Pastorello
  • G Pauli
  • T Platts-Mills
  • D Posa
  • L K Poulsen
  • M Raulf
  • J Sastre
  • E Scala
  • J M Schmid
  • P Schmid-Grendelmeier
  • M van Hage
  • R van Ree
  • S Vieths
  • R Weber
  • M Wickman
  • A Muraro
  • M Ollert
Vis graf over relationer

The availability of allergen molecules ('components') from several protein families has advanced our understanding of immunoglobulin E (IgE)-mediated responses and enabled 'component-resolved diagnosis' (CRD). The European Academy of Allergy and Clinical Immunology (EAACI) Molecular Allergology User's Guide (MAUG) provides comprehensive information on important allergens and describes the diagnostic options using CRD. Part A of the EAACI MAUG introduces allergen molecules, families, composition of extracts, databases, and diagnostic IgE, skin, and basophil tests. Singleplex and multiplex IgE assays with components improve both sensitivity for low-abundance allergens and analytical specificity; IgE to individual allergens can yield information on clinical risks and distinguish cross-reactivity from true primary sensitization. Part B discusses the clinical and molecular aspects of IgE-mediated allergies to foods (including nuts, seeds, legumes, fruits, vegetables, cereal grains, milk, egg, meat, fish, and shellfish), inhalants (pollen, mold spores, mites, and animal dander), and Hymenoptera venom. Diagnostic algorithms and short case histories provide useful information for the clinical workup of allergic individuals targeted for CRD. Part C covers protein families containing ubiquitous, highly cross-reactive panallergens from plant (lipid transfer proteins, polcalcins, PR-10, profilins) and animal sources (lipocalins, parvalbumins, serum albumins, tropomyosins) and explains their diagnostic and clinical utility. Part D lists 100 important allergen molecules. In conclusion, IgE-mediated reactions and allergic diseases, including allergic rhinoconjunctivitis, asthma, food reactions, and insect sting reactions, are discussed from a novel molecular perspective. The EAACI MAUG documents the rapid progression of molecular allergology from basic research to its integration into clinical practice, a quantum leap in the management of allergic patients.

OriginalsprogEngelsk
TidsskriftPediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology
Vol/bind27 Suppl 23
Sider (fra-til)1-250
Antal sider250
ISSN0905-6157
DOI
StatusUdgivet - maj 2016

Bibliografisk note

© 2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.

ID: 59016794