Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Initiation of MLL-rearranged AML is dependent on C/EBPα

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Autocrine VEGF-VEGFR2-Neuropilin-1 signaling promotes glioma stem-like cell viability and tumor growth

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Identification of serum metabolites associated with renal impairment: A metabolomics study in Type 1 Diabetes

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  2. Serum metabolites associate with CT findings following TBI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Plasma Metabolomics Profiling in Auto-Antibody-Positive Individuals Progressing to Type 1 Diabetes

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  4. SERUM METABOLITES ASSOCIATE WITH HEAD COMPUTED TOMOGRAPHY FINDINGS FOLLOWING TRAUMATIC BRAIN INJURY

    Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  • Matej Oresic
  • Satu Simell
  • Marko Sysi-Aho
  • Kirsti Näntö-Salonen
  • Tuulikki Seppänen-Laakso
  • Vilhelmiina Parikka
  • Mikko Katajamaa
  • Anne Hekkala
  • Ismo Mattila
  • Päivi Keskinen
  • Laxman Yetukuri
  • Arja Reinikainen
  • Jyrki Lähde
  • Tapani Suortti
  • Jari Hakalax
  • Tuula Simell
  • Heikki Hyöty
  • Riitta Veijola
  • Jorma Ilonen
  • Riitta Lahesmaa
  • Mikael Knip
  • Olli Simell
Vis graf over relationer

The risk determinants of type 1 diabetes, initiators of autoimmune response, mechanisms regulating progress toward beta cell failure, and factors determining time of presentation of clinical diabetes are poorly understood. We investigated changes in the serum metabolome prospectively in children who later progressed to type 1 diabetes. Serum metabolite profiles were compared between sample series drawn from 56 children who progressed to type 1 diabetes and 73 controls who remained nondiabetic and permanently autoantibody negative. Individuals who developed diabetes had reduced serum levels of succinic acid and phosphatidylcholine (PC) at birth, reduced levels of triglycerides and antioxidant ether phospholipids throughout the follow up, and increased levels of proinflammatory lysoPCs several months before seroconversion to autoantibody positivity. The lipid changes were not attributable to HLA-associated genetic risk. The appearance of insulin and glutamic acid decarboxylase autoantibodies was preceded by diminished ketoleucine and elevated glutamic acid. The metabolic profile was partially normalized after the seroconversion. Autoimmunity may thus be a relatively late response to the early metabolic disturbances. Recognition of these preautoimmune alterations may aid in studies of disease pathogenesis and may open a time window for novel type 1 diabetes prevention strategies.

OriginalsprogEngelsk
TidsskriftJournal of Experimental Medicine
Vol/bind205
Udgave nummer13
Sider (fra-til)2975-84
Antal sider10
ISSN0022-1007
DOI
StatusUdgivet - 22 dec. 2008
Eksternt udgivetJa

ID: 54987747