Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Dysphagia is prevalent in patients with CPEO and single, large-scale deletions in mtDNA

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Plasma lactate responses during and after submaximal handgrip exercise are not diagnostically helpful in mitochondrial myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Mitochondrion-driven nephroprotective mechanisms of novel glucose lowering medications

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  3. Growth and differentiation factor 15 as a biomarker for mitochondrial myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Muscle contractility of leg muscles in patients with mitochondrial myopathies

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Habitual Physical Activity in Patients with Myasthenia Gravis Assessed by Accelerometry and Questionnaire

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Muscle biopsy and MRI findings in ANO5-related myopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

BACKGROUND: The aim of this study was to assess the frequency of subjective and objective dysphagia in patients with chronic progressive external ophthalmoplegia (CPEO) due to single, large-scale deletions (LSDs) of mitochondrial DNA (mtDNA).

METHODS: Sixteen patients with CPEO and single LSDs of mtDNA were included in the study and compared to a control group of 12 patients with the m.3243A>G mtDNA mutation. Patients had to drink 80ml of water at 4°C as fast as they could (cold-water test) and fill out a standardized questionnaire about dysphagia.

RESULTS: Eight patients (50%) with CPEO and single LSDs of mtDNA had a prolonged cold-water test, including one with a PEG-tube, who was unable to perform the test, and nine patients reported subjective swallowing problems (56.3%). All mitochondrial myopathy patients in the control group had a normal duration of the cold-water test.

CONCLUSIONS: The study shows that dysphagia is a common problem in patients with CPEO and LSDs of mtDNA. Dysphagia seems to be progressive with age as abnormal swallowing occurred preferentially in persons ≥45years. The study shows that increased awareness of this symptom should be given to address appropriate treatment interventions and avoid complications such as social isolation, malnutrition and aspiration pneumonia.

OriginalsprogEngelsk
TidsskriftMitochondrion
Vol/bind32
Sider (fra-til)27-30
Antal sider4
ISSN1567-7249
DOI
StatusUdgivet - 14 nov. 2016

ID: 49294049