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Dynamic nuclear polarization and optimal control spatial-selective (13)C MRI and MRS

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Multi-site benchmarking of clinical 13C RF coils at 3T

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. In vivo single-shot 13C spectroscopic imaging of hyperpolarized metabolites by spatiotemporal encoding

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Planar quadrature coil design using shielded-loop resonators.

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Multi-site benchmarking of clinical 13C RF coils at 3T

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. High Intrarenal Lactate Production Inhibits the Renal Pseudohypoxic Response to Acutely Induced Hypoxia in Diabetes

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Hyperpolarized 13C MRI: Path to Clinical Translation in Oncology

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  4. Calibrated Coil Combination for Fixed-Geometry, Low-Frequency Coils with Application to Hyperpolarized 13C Measurements

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  5. Data-driven Nyquist ghost correction for hyperpolarized 13C EPSI and EPI

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

Vis graf over relationer
Aimed at 13C metabolic magnetic resonance imaging (MRI) and spectroscopy (MRS) applications, we demonstrate that dynamic nuclear polarization (DNP) may be combined with optimal control 2D spatial selection to simultaneously obtain high sensitivity and well-defined spatial restriction. This is achieved through the development of spatial-selective single-shot spiral-readout MRI and MRS experiments combined with dynamic nuclear polarization hyperpolarized [1-13C]pyruvate on a 4.7 T pre-clinical MR scanner. The method stands out from related techniques by facilitating anatomic shaped region-of-interest (ROI) single metabolite signals available for higher image resolution or single-peak spectra. The 2D spatial-selective rf pulses were designed using a novel Krotov-based optimal control approach capable of iteratively fast providing successful pulse sequences in the absence of qualified initial guesses. The technique may be important for early detection of abnormal metabolism, monitoring disease progression, and drug research.
OriginalsprogEngelsk
TidsskriftJournal of Magnetic Resonance
Vol/bind227
Sider (fra-til)57-61
Antal sider5
DOI
StatusUdgivet - feb. 2013

ID: 36848576