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Dynamic coupling of whole-brain neuronal and neurotransmitter systems

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Kringelbach, ML, Cruzat, J, Cabral, J, Knudsen, GM, Carhart-Harris, R, Whybrow, PC, Logothetis, NK & Deco, G 2020, 'Dynamic coupling of whole-brain neuronal and neurotransmitter systems' Proceedings of the National Academy of Sciences of the United States of America, bind 117, nr. 17, s. 9566-9576. https://doi.org/10.1073/pnas.1921475117

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Author

Kringelbach, Morten L ; Cruzat, Josephine ; Cabral, Joana ; Knudsen, Gitte Moos ; Carhart-Harris, Robin ; Whybrow, Peter C ; Logothetis, Nikos K ; Deco, Gustavo. / Dynamic coupling of whole-brain neuronal and neurotransmitter systems. I: Proceedings of the National Academy of Sciences of the United States of America. 2020 ; Bind 117, Nr. 17. s. 9566-9576.

Bibtex

@article{05c859e103934efea15fad4290686ab0,
title = "Dynamic coupling of whole-brain neuronal and neurotransmitter systems",
abstract = "Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to explain through long-term plasticity. Neuromodulation evolved to allow for such flexibility by dynamically updating the effectivity of the fixed anatomical connectivity. Here, we introduce a theoretical framework modeling the dynamical mutual coupling between the neuronal and neurotransmitter systems. We demonstrate that this framework is crucial to advance our understanding of whole-brain dynamics by bidirectional coupling of the two systems through combining multimodal neuroimaging data (diffusion magnetic resonance imaging [dMRI], functional magnetic resonance imaging [fMRI], and positron electron tomography [PET]) to explain the functional effects of specific serotoninergic receptor (5-HT2AR) stimulation with psilocybin in healthy humans. This advance provides an understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction. Overall, these insights demonstrate that the whole-brain mutual coupling between the neuronal and the neurotransmission systems is essential for understanding the remarkable flexibility of human brain function despite having to rely on fixed anatomical connectivity.",
author = "Kringelbach, {Morten L} and Josephine Cruzat and Joana Cabral and Knudsen, {Gitte Moos} and Robin Carhart-Harris and Whybrow, {Peter C} and Logothetis, {Nikos K} and Gustavo Deco",
note = "Copyright {\circledC} 2020 the Author(s). Published by PNAS.",
year = "2020",
month = "4",
day = "28",
doi = "10.1073/pnas.1921475117",
language = "English",
volume = "117",
pages = "9566--9576",
journal = "National Academy of Sciences. Proceedings",
issn = "0027-8424",
publisher = "National Academy of Sciences",
number = "17",

}

RIS

TY - JOUR

T1 - Dynamic coupling of whole-brain neuronal and neurotransmitter systems

AU - Kringelbach, Morten L

AU - Cruzat, Josephine

AU - Cabral, Joana

AU - Knudsen, Gitte Moos

AU - Carhart-Harris, Robin

AU - Whybrow, Peter C

AU - Logothetis, Nikos K

AU - Deco, Gustavo

N1 - Copyright © 2020 the Author(s). Published by PNAS.

PY - 2020/4/28

Y1 - 2020/4/28

N2 - Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to explain through long-term plasticity. Neuromodulation evolved to allow for such flexibility by dynamically updating the effectivity of the fixed anatomical connectivity. Here, we introduce a theoretical framework modeling the dynamical mutual coupling between the neuronal and neurotransmitter systems. We demonstrate that this framework is crucial to advance our understanding of whole-brain dynamics by bidirectional coupling of the two systems through combining multimodal neuroimaging data (diffusion magnetic resonance imaging [dMRI], functional magnetic resonance imaging [fMRI], and positron electron tomography [PET]) to explain the functional effects of specific serotoninergic receptor (5-HT2AR) stimulation with psilocybin in healthy humans. This advance provides an understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction. Overall, these insights demonstrate that the whole-brain mutual coupling between the neuronal and the neurotransmission systems is essential for understanding the remarkable flexibility of human brain function despite having to rely on fixed anatomical connectivity.

AB - Remarkable progress has come from whole-brain models linking anatomy and function. Paradoxically, it is not clear how a neuronal dynamical system running in the fixed human anatomical connectome can give rise to the rich changes in the functional repertoire associated with human brain function, which is impossible to explain through long-term plasticity. Neuromodulation evolved to allow for such flexibility by dynamically updating the effectivity of the fixed anatomical connectivity. Here, we introduce a theoretical framework modeling the dynamical mutual coupling between the neuronal and neurotransmitter systems. We demonstrate that this framework is crucial to advance our understanding of whole-brain dynamics by bidirectional coupling of the two systems through combining multimodal neuroimaging data (diffusion magnetic resonance imaging [dMRI], functional magnetic resonance imaging [fMRI], and positron electron tomography [PET]) to explain the functional effects of specific serotoninergic receptor (5-HT2AR) stimulation with psilocybin in healthy humans. This advance provides an understanding of why psilocybin is showing considerable promise as a therapeutic intervention for neuropsychiatric disorders including depression, anxiety, and addiction. Overall, these insights demonstrate that the whole-brain mutual coupling between the neuronal and the neurotransmission systems is essential for understanding the remarkable flexibility of human brain function despite having to rely on fixed anatomical connectivity.

U2 - 10.1073/pnas.1921475117

DO - 10.1073/pnas.1921475117

M3 - Journal article

VL - 117

SP - 9566

EP - 9576

JO - National Academy of Sciences. Proceedings

JF - National Academy of Sciences. Proceedings

SN - 0027-8424

IS - 17

ER -

ID: 60077465