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Dual-volume excitation and parallel reconstruction for J-difference-edited MR spectroscopy

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Quantification of cerebral perfusion and cerebrovascular reserve using Turbo-QUASAR arterial spin labeling MRI

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Coil profile estimation strategies for parallel imaging with hyperpolarized 13 C MRI

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  3. Gamma-aminobutyric acid edited echo-planar spectroscopic imaging (EPSI) with MEGA-sLASER at 7T

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  4. Comparison of prospective head motion correction with NMR field probes and an optical tracking system

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Improved calculation of the equilibrium magnetization of arterial blood in arterial spin labeling

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Prospective motion correction in single voxel spectroscopy at 7T using fat navigators and higher order shimming

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  2. Pre-Acquisition Adjustments (B0 Shimming, B1 Shimming & Water Suppression)

    Publikation: KonferencebidragKonferenceabstrakt til konferenceForskningpeer review

  3. Ultra-high field MR angiography in human migraine models: a 3.0 T/7.0 T comparison study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Georg Oeltzschner
  • Nicolaas A J Puts
  • Kimberly L Chan
  • Vincent Boer
  • Peter B Barker
  • Richard A E Edden
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PURPOSE: To develop J-difference editing with parallel reconstruction in accelerated multivoxel (PRIAM) for simultaneous measurement in two separate brain regions of γ-aminobutyric acid (GABA) or glutathione.

METHODS: PRIAM separates signals from two simultaneously excited voxels using receiver-coil sensitivity profiles. PRIAM was implemented into Mescher-Garwood (MEGA) edited experiments at 3 Tesla (T), and validated by acquiring dual-voxel MEGA-PRIAM (and compared with conventional single-voxel MEGA-PRESS) spectra from a GABA/glutathione phantom, and 11 healthy participants.

RESULTS: MEGA-PRIAM effectively separated phantom spectra with ∼3-4% between-voxel contamination. GABA and glutathione measurements agreed well with those obtained using single-voxel MEGA-PRESS (mean difference was below 2% in GABA levels, and below 7% in glutathione levels). In vivo, GABA- and glutathione-edited spectra were successfully reconstructed with a mean in vivo g-factor of 1.025 (typical voxel-center separation: 7-8 cm). MEGA-PRIAM experiments showed higher signal-to-noise ratio than sequential single-voxel experiments of the same total duration (mean improvement 1.38 ± 0.24).

CONCLUSIONS: Simultaneous acquisition of J-difference-edited GABA or glutathione spectra from two voxels is feasible at 3 T. MEGA-PRIAM increases data acquisition rates compared with MEGA-PRESS by a factor of 2. Magn Reson Med, 2016. © 2016 International Society for Magnetic Resonance in Medicine.

OriginalsprogEngelsk
TidsskriftMagnetic Resonance in Medicine
Vol/bind77
Udgave nummer1
Sider (fra-til)16-22
ISSN0740-3194
DOI
StatusUdgivet - jan. 2017

ID: 49232737