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Region Hovedstaden - en del af Københavns Universitetshospital
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Drug-drug interactions between vitamin K antagonists and statins: a systematic review

Publikation: Bidrag til tidsskriftReviewForskningpeer review

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Vis graf over relationer

PURPOSE: Concomitant use of vitamin K antagonists (VKA) and statins is frequent in cardiovascular patients. However, clinical guidelines on this drug combination are divergent. Therefore, we performed a systematic review to evaluate the effect of statin initiation on coagulation among VKA users.

METHODS: Following the PRISMA guidelines, we applied two broad search strategies for the drug interaction between VKA and statins in both Embase and Pubmed; 8623 unique hits were obtained. In the final sample, eight studies were included.

RESULTS: The most frequently used VKA in the studies was warfarin, while simvastatin was the most commonly initiated statin. All included studies showed a minor increase in the anticoagulant effect of VKA following statin initiation during VKA treatment. The reported increases in mean international normalized ratio (INR) ranged from 0.15-0.65.

CONCLUSION: The anticoagulant effect of statin initiation in patients treated with VKA is likely to be of limited clinical relevance but should be evaluated individually.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Clinical Pharmacology
Vol/bind77
Udgave nummer10
Sider (fra-til)1435-1441
Antal sider7
ISSN0031-6970
DOI
StatusUdgivet - okt. 2021

Bibliografisk note

Funding Information:
TBS reports personal fees from Pfizer, Eisai, and Astellas Pharma, outside the submitted work. TBS has done consulting and paid lectures for Pfizer and paid lectures for Eisai and Astellas Pharma with no relation to the submitted work. AP reports participation in research projects funded by Alcon, Almirall, Astellas, Astra-Zeneca, Boehringer-Ingelheim, Novo Nordisk, Servier, and LEO Pharma, all with funds paid to the institution where he was employed (no personal fees) and with no relation to the work.

ID: 65427173