TY - JOUR
T1 - Drug use in patients with short bowel syndrome and intestinal failure
AU - Vorre, Mette Medom
AU - Johansson, Karl Sebastian
AU - Fuglsang, Kristian Asp
AU - Horwitz, Henrik
AU - Solem, Espen Jimenez
AU - Jeppesen, Palle Bekker
AU - Christensen, Mikkel Bring
N1 - Articles published in the DMJ are “open access”. This means that the articles are distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits any non-commercial use, distribution, and reproduction in any medium, provided the original author(s) and source are credited.
PY - 2022/4/28
Y1 - 2022/4/28
N2 - INTRODUCTION: In patients with short bowel syndrome (SBS), severe malabsorption may cause a need for parenteral support and, by definition, these patients suffer from SBS intestinal failure. Absorption of oral medications is likely diminished in patients with SBS intestinal failure and higher than normal doses may be required to achieve sufficient pharmacologic effect. We investigated the prescription patterns and oral dosages in a well-defined population of patients with non-malignant SBS intestinal failure.METHODS: This was a cross-sectional analysis based on a cohort of adult patients with SBS intestinal failure treated with home parenteral support and registered in 2016 at the Department of Gastroenterology at the Copenhagen University Hospital - Rigshospitalet. The patients' clinical data and prescription patterns were extracted from electronic medical and medications records.RESULTS: The patients in our cohort (n = 74) were primarily females (58%), the median age was 63 years (interquartile range (IQR): 52-72 years) and the median BMI was 22 kg/m2 (IQR: 19-26 kg/m2). Each patient was treated with a median of eight drugs (range: 1-20). Most (75%) of the medications were administered orally. Only codeine, levothyroxine and loperamide were prescribed in higher dosages than recommended in their product labelling. All medication-treated patients were prescribed between one and four different analgesics.CONCLUSION: In our single-centre cohort of patients with SBS intestinal failure, orally administered medications were generally prescribed in recommended dosages.FUNDING: none Trial registration. Approved by the Danish Data Protection Agency (BFH-2016-058, I-Suite no.: 04906) and the Danish Patient Safety Authority (3-3013-1884/1/).
AB - INTRODUCTION: In patients with short bowel syndrome (SBS), severe malabsorption may cause a need for parenteral support and, by definition, these patients suffer from SBS intestinal failure. Absorption of oral medications is likely diminished in patients with SBS intestinal failure and higher than normal doses may be required to achieve sufficient pharmacologic effect. We investigated the prescription patterns and oral dosages in a well-defined population of patients with non-malignant SBS intestinal failure.METHODS: This was a cross-sectional analysis based on a cohort of adult patients with SBS intestinal failure treated with home parenteral support and registered in 2016 at the Department of Gastroenterology at the Copenhagen University Hospital - Rigshospitalet. The patients' clinical data and prescription patterns were extracted from electronic medical and medications records.RESULTS: The patients in our cohort (n = 74) were primarily females (58%), the median age was 63 years (interquartile range (IQR): 52-72 years) and the median BMI was 22 kg/m2 (IQR: 19-26 kg/m2). Each patient was treated with a median of eight drugs (range: 1-20). Most (75%) of the medications were administered orally. Only codeine, levothyroxine and loperamide were prescribed in higher dosages than recommended in their product labelling. All medication-treated patients were prescribed between one and four different analgesics.CONCLUSION: In our single-centre cohort of patients with SBS intestinal failure, orally administered medications were generally prescribed in recommended dosages.FUNDING: none Trial registration. Approved by the Danish Data Protection Agency (BFH-2016-058, I-Suite no.: 04906) and the Danish Patient Safety Authority (3-3013-1884/1/).
KW - Adult
KW - Cohort Studies
KW - Cross-Sectional Studies
KW - Female
KW - Humans
KW - Intestinal Failure
KW - Middle Aged
KW - Parenteral Nutrition
KW - Short Bowel Syndrome/drug therapy
UR - https://ugeskriftet.dk/dmj/drug-use-patients-short-bowel-syndrome-and-intestinal-failure
M3 - Journal article
C2 - 35485788
VL - 69
JO - Danish Medical Bulletin (Online)
JF - Danish Medical Bulletin (Online)
SN - 1603-9629
IS - 5
ER -