@article{ecd532fe430c4165a8a3ade82d768ca2,
title = "Drug-eluting versus bare metal stents in patients with st-segment-elevation myocardial infarction: eight-month follow-up in the Drug Elution and Distal Protection in Acute Myocardial Infarction (DEDICATION) trial",
abstract = "BACKGROUND: Implantation of drug-eluting stents (DES) limits the rate of coronary restenosis in most patients with coronary artery disease, but data are scarce with regard to their use in patients with ST-segment-elevation myocardial infarction and in connection with distal protection of the microvascular perfusion during primary percutaneous coronary intervention. METHODS AND RESULTS: We randomly assigned 626 patients referred within 12 hours from symptom onset of an ST-elevation myocardial infarction to have a DES or a bare metal stent implanted in the infarct-related lesion with or without distal protection during primary percutaneous coronary intervention. Quantitative coronary angiography was performed during the index treatment and 8 months later. The primary end point was loss of the lumen diameter in the infarct-related lesion induced by neointimal proliferation. Patients were comparable with regard to baseline demographic and angiographic characteristics. The mean late lumen loss was significantly lower in patients treated with a DES (0.06 mm; SD, 0.66 mm) than in patients who had a bare metal stent implanted (0.47 mm; SD, 0.69 mm; P<0.001). The rate of the composite end point of cardiac death, recurrent myocardial infarction, and target lesion revascularization was 8.6\% in the DES group versus 14.4\% in the bare metal stent group (P=0.03). Cardiac death occurred in 4.2\% and 1.6\% of the patients (P=0.09) and stent thrombosis occurred in 2.0\% and 2.6\% (P=0.72), respectively. CONCLUSIONS: Implantation of DES improves the angiographic outcome and need for repeat revascularization without increasing the short-term risk of stent thrombosis but has a tendency to increase cardiac death in patients with ST-segment-elevation myocardial infarction.",
keywords = "Angioplasty, Transluminal, Percutaneous Coronary, Cell Proliferation, Coronary Angiography, Coronary Artery Disease, Coronary Stenosis, Death, Drug-Eluting Stents, Follow-Up Studies, Humans, Myocardial Infarction, Stents, Thrombosis, Treatment Outcome, Tunica Intima",
author = "Henning Kelbaek and Leif Thuesen and Steffen Helqvist and Peter Clemmensen and Lene Kl{\o}vgaard and Anne Kaltoft and Bente Andersen and Helle Thuesen and Thomas Engstr{\o}m and B{\o}tker, \{Hans E\} and Kari Saunam{\"a}ki and Krusell, \{Lars R\} and Erik J{\o}rgensen and Hansen, \{Hans-Henrik T\} and Christiansen, \{Evald H\} and Jan Ravkilde and Lars K{\o}ber and Kofoed, \{Klaus F\} and Terkelsen, \{Christian J\} and Lassen, \{Jens F\} and NN NN",
year = "2008",
doi = "10.1161/CIRCULATIONAHA.107.758698",
language = "English",
volume = "118",
pages = "1155--62",
journal = "Circulation (Baltimore)",
issn = "0009-7322",
publisher = "Lippincott Williams and Wilkins",
number = "11",
}