Doubling the infliximab dose versus halving the infusion intervals in Crohn's disease patients with loss of response

Lior Katz, Javier P Gisbert, Beth Manoogian, Kirk Lin, Casper Steenholdt, Gerassimos J Mantzaris, Ashish Atreja, Yulia Ron, Arun Swaminath, Somal Shah, Ailsa Hart, Peter Laszlo Lakatos, Pierre Ellul, Eran Israeli, Mads Naundrup Svendsen, C Janneke van der Woude, Konstantinos H Katsanos, Laura Yun, Epameinondas V Tsianos, Torben NathanMaria Abreu, Iris Dotan, Bret Lashner, Jorn Brynskov, Jonathan P Terdiman, Peter D R Higgins, Maria Chaparro, Shomron Ben-Horin

129 Citationer (Scopus)

Abstract

Intensifying infliximab therapy is often practiced in Crohn's disease (CD) patients losing response to the drug but there are no data if halving the interval is superior to doubling the dose. We aimed to assess the efficacy of infliximab dose intensification by interval-halving compared with dose-doubling.
OriginalsprogEngelsk
TidsskriftInflammatory Bowel Diseases
Vol/bind18
Udgave nummer11
Sider (fra-til)2026-33
Antal sider8
ISSN1078-0998
DOI
StatusUdgivet - 2012

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