Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia

K H Scheuer, K Svenstrup, P Jennum, B á Rogvi-Hansen, L Werdelin, K Fenger, J E Nielsen

Abstract

Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.

OriginalsprogEngelsk
TidsskriftEuropean Journal of Neurology
Vol/bind14
Udgave nummer6
Sider (fra-til)663-6
Antal sider4
ISSN1351-5101
DOI
StatusUdgivet - jun. 2007

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