@article{46313b5d8ca44372954f5ca3a7e7d772,
title = "Double-blind crossover trial of gabapentin in SPG4-linked hereditary spastic paraplegia",
abstract = "Patients with hereditary spastic paraplegia (HSP) are often treated with antispastic drugs to relieve symptoms but documentation is lacking. In this study, gabapentin was tested in a double-blind crossover trial on a group of patients with HSP and linkage to the SPG4 locus. There was no difference between periods with gabapentin and placebo treatment in clinical assessment, self-reported parameters or paired transcranial magnetic stimulation evaluation of motor cortical excitability.",
keywords = "Adenosine Triphosphatases/genetics, Adult, Aged, Amines/therapeutic use, Anticonvulsants/therapeutic use, Cross-Over Studies, Cyclohexanecarboxylic Acids/therapeutic use, Double-Blind Method, Female, Gabapentin, Humans, Male, Middle Aged, Spastic Paraplegia, Hereditary/drug therapy, Spastin, Statistics, Nonparametric, gamma-Aminobutyric Acid/therapeutic use",
author = "Scheuer, {K H} and K Svenstrup and P Jennum and Rogvi-Hansen, {B {\'a}} and L Werdelin and K Fenger and Nielsen, {J E}",
year = "2007",
month = jun,
doi = "10.1111/j.1468-1331.2007.01812.x",
language = "English",
volume = "14",
pages = "663--6",
journal = "European Journal of Neurology",
issn = "1351-5101",
publisher = "Wiley-Blackwell Publishing Ltd",
number = "6",
}