Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors

Maiwand Ahmadsei; Vinojaa Jegarajah; Riccardo Dal Bello; Sebastian M Christ; Michael M Mayinger; Luisa Sabrina Stark; Jonas Willmann; Ivan R Vogelius; Panagiotis Balermpas; Nicolaus Andratschke; Stephanie Tanadini-Lang; Matthias Guckenberger

doi:10.1016/j.ctro.2023.100707

Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors

Maiwand Ahmadsei^*, Vinojaa Jegarajah, Riccardo Dal Bello, Sebastian M Christ, Michael M Mayinger, Luisa Sabrina Stark, Jonas Willmann, Ivan R Vogelius, Panagiotis Balermpas, Nicolaus Andratschke, Stephanie Tanadini-Lang, Matthias Guckenberger

^*Corresponding author af dette arbejde

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Abstract

•Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors is associated with high toxicity rates.•To evaluate differences in radiosensitivity within the proximal bronchial tree (PBT), the PBT was sub-segmented into seven anatomical sections.•A risk-adapted SBRT regimen of EQD2_10 = 54.4 Gy in 8 or 10 fractions results in excellent local control and low rates of severe toxicity.•Data from a recent meta-analysis, the NORDIC Hilus trial and dosimetric data from this study were combined to create a NTCP model.•A dose threshold of EQD2_3 = 100 Gy to the PBT or any of its subsegments is expected to result in low rates of severe bronchial toxicity.

Originalsprog	Engelsk
Artikelnummer	100707
Tidsskrift	Clinical and Translational Radiation Oncology
Vol/bind	45
ISSN	2405-6308
DOI	https://doi.org/10.1016/j.ctro.2023.100707
Status	Udgivet - mar. 2024

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10.1016/j.ctro.2023.100707Licens: CC BY

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Ahmadsei, M., Jegarajah, V., Dal Bello, R., Christ, S. M., Mayinger, M. M., Sabrina Stark, L., Willmann, J., Vogelius, I. R., Balermpas, P., Andratschke, N., Tanadini-Lang, S., & Guckenberger, M. (2024). Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors. Clinical and Translational Radiation Oncology, 45, Artikel 100707. https://doi.org/10.1016/j.ctro.2023.100707

Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors. / Ahmadsei, Maiwand; Jegarajah, Vinojaa; Dal Bello, Riccardo et al.
I: Clinical and Translational Radiation Oncology, Bind 45, 100707, 03.2024.

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › Forskning › peer review

Ahmadsei, M, Jegarajah, V, Dal Bello, R, Christ, SM, Mayinger, MM, Sabrina Stark, L, Willmann, J, Vogelius, IR, Balermpas, P, Andratschke, N, Tanadini-Lang, S & Guckenberger, M 2024, 'Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors', Clinical and Translational Radiation Oncology, bind 45, 100707. https://doi.org/10.1016/j.ctro.2023.100707

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title = "Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors",

abstract = "•Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors is associated with high toxicity rates.•To evaluate differences in radiosensitivity within the proximal bronchial tree (PBT), the PBT was sub-segmented into seven anatomical sections.•A risk-adapted SBRT regimen of EQD2_10 = 54.4 Gy in 8 or 10 fractions results in excellent local control and low rates of severe toxicity.•Data from a recent meta-analysis, the NORDIC Hilus trial and dosimetric data from this study were combined to create a NTCP model.•A dose threshold of EQD2_3 = 100 Gy to the PBT or any of its subsegments is expected to result in low rates of severe bronchial toxicity.",

author = "Maiwand Ahmadsei and Vinojaa Jegarajah and {Dal Bello}, Riccardo and Christ, {Sebastian M} and Mayinger, {Michael M} and {Sabrina Stark}, Luisa and Jonas Willmann and Vogelius, {Ivan R} and Panagiotis Balermpas and Nicolaus Andratschke and Stephanie Tanadini-Lang and Matthias Guckenberger",

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year = "2024",

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doi = "10.1016/j.ctro.2023.100707",

language = "English",

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journal = "Clinical and Translational Radiation Oncology",

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AU - Ahmadsei, Maiwand

AU - Jegarajah, Vinojaa

AU - Dal Bello, Riccardo

AU - Christ, Sebastian M

AU - Mayinger, Michael M

AU - Sabrina Stark, Luisa

AU - Willmann, Jonas

AU - Vogelius, Ivan R

AU - Balermpas, Panagiotis

AU - Andratschke, Nicolaus

AU - Tanadini-Lang, Stephanie

AU - Guckenberger, Matthias

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N2 - •Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors is associated with high toxicity rates.•To evaluate differences in radiosensitivity within the proximal bronchial tree (PBT), the PBT was sub-segmented into seven anatomical sections.•A risk-adapted SBRT regimen of EQD2_10 = 54.4 Gy in 8 or 10 fractions results in excellent local control and low rates of severe toxicity.•Data from a recent meta-analysis, the NORDIC Hilus trial and dosimetric data from this study were combined to create a NTCP model.•A dose threshold of EQD2_3 = 100 Gy to the PBT or any of its subsegments is expected to result in low rates of severe bronchial toxicity.

AB - •Stereotactic body radiation therapy (SBRT) for ultra-central lung tumors is associated with high toxicity rates.•To evaluate differences in radiosensitivity within the proximal bronchial tree (PBT), the PBT was sub-segmented into seven anatomical sections.•A risk-adapted SBRT regimen of EQD2_10 = 54.4 Gy in 8 or 10 fractions results in excellent local control and low rates of severe toxicity.•Data from a recent meta-analysis, the NORDIC Hilus trial and dosimetric data from this study were combined to create a NTCP model.•A dose threshold of EQD2_3 = 100 Gy to the PBT or any of its subsegments is expected to result in low rates of severe bronchial toxicity.

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U2 - 10.1016/j.ctro.2023.100707

DO - 10.1016/j.ctro.2023.100707

M3 - Journal article

C2 - 38125648

SN - 2405-6308

VL - 45

JO - Clinical and Translational Radiation Oncology

JF - Clinical and Translational Radiation Oncology

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ER -

Dosimetric Analysis of Proximal Bronchial Tree Subsegments to Assess The Risk of Severe Toxicity After Stereotactic Body Radiation Therapy of Ultra-central Lung Tumors

Abstract

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