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Dose-Dependent Associations of Dietary Glycemic Index, Glycemic Load, and Fiber With 3-Year Weight Loss Maintenance and Glycemic Status in a High-Risk Population: A Secondary Analysis of the Diabetes Prevention Study PREVIEW

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DOI

  1. Effect of Dairy Matrix on the Postprandial Blood Metabolome

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Matrix structure of dairy products results in different postprandial lipid responses: a randomized crossover trial

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. What Is the Profile of Overweight Individuals Who Are Unsuccessful Responders to a Low-Energy Diet? A PREVIEW Sub-study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  • Ruixin Zhu
  • Thomas M Larsen
  • Mikael Fogelholm
  • Sally D Poppitt
  • Pia S Vestentoft
  • Marta P Silvestre
  • Elli Jalo
  • Santiago Navas-Carretero
  • Maija Huttunen-Lenz
  • Moira A Taylor
  • Gareth Stratton
  • Nils Swindell
  • Mathijs Drummen
  • Tanja C Adam
  • Christian Ritz
  • Jouko Sundvall
  • Liisa M Valsta
  • Roslyn Muirhead
  • Shannon Brodie
  • Teodora Handjieva-Darlenska
  • Svetoslav Handjiev
  • J Alfredo Martinez
  • Ian A Macdonald
  • Margriet S Westerterp-Plantenga
  • Jennie Brand-Miller
  • Anne Raben
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OBJECTIVE: To examine longitudinal and dose-dependent associations of dietary glycemic index (GI), glycemic load (GL), and fiber with body weight and glycemic status during 3-year weight loss maintenance (WLM) in adults at high risk of type 2 diabetes.

RESEARCH DESIGN AND METHODS: In this secondary analysis we used pooled data from the PREVention of diabetes through lifestyle Intervention and population studies in Europe and around the World (PREVIEW) randomized controlled trial, which was designed to test the effects of four diet and physical activity interventions. A total of 1,279 participants with overweight or obesity (age 25-70 years and BMI ≥25 kg ⋅ m-2) and prediabetes at baseline were included. We used multiadjusted linear mixed models with repeated measurements to assess longitudinal and dose-dependent associations by merging the participants into one group and dividing them into GI, GL, and fiber tertiles, respectively.

RESULTS: In the available-case analysis, each 10-unit increment in GI was associated with a greater regain of weight (0.46 kg ⋅ year-1; 95% CI 0.23, 0.68; P < 0.001) and increase in HbA1c. Each 20-unit increment in GL was associated with a greater regain of weight (0.49 kg ⋅ year-1; 0.24, 0.75; P < 0.001) and increase in HbA1c. The associations of GI and GL with HbA1c were independent of weight change. Compared with those in the lowest tertiles, participants in the highest GI and GL tertiles had significantly greater weight regain and increases in HbA1c. Fiber was inversely associated with increases in waist circumference, but the associations with weight regain and glycemic status did not remain robust in different analyses.

CONCLUSIONS: Dietary GI and GL were positively associated with weight regain and deteriorating glycemic status. Stronger evidence on the role of fiber is needed.

OriginalsprogEngelsk
TidsskriftDiabetes Care
Vol/bind44
Udgave nummer7
Sider (fra-til)1672-1681
Antal sider10
ISSN1935-5548
DOI
StatusUdgivet - jul. 2021

Bibliografisk note

© 2021 by the American Diabetes Association.

ID: 69353583