@article{afde450c035c41358e34a83ba24c2b52,
title = "Dose-ranging evaluation of intravitreal siRNA PF-04523655 for diabetic macular edema (the DEGAS study)",
abstract = "To evaluate the safety and efficacy of three doses of PF-04523655, a 19-nucleotide methylated double stranded siRNA targeting the RTP801 gene, for the treatment of diabetic macular edema (DME) compared to focal/grid laser photocoagulation.",
keywords = "Adult, Aged, Aged, 80 and over, Diabetic Retinopathy, Dose-Response Relationship, Drug, Double-Blind Method, Female, Follow-Up Studies, Humans, Intravitreal Injections, Macula Lutea, Macular Edema, Male, Middle Aged, Prospective Studies, RNA, Small Interfering, Tomography, Optical Coherence, Treatment Outcome, Visual Acuity",
author = "Nguyen, {Quan Dong} and Schachar, {Ronald A} and Nduaka, {Chudy I} and Marvin Sperling and Basile, {Anthony S} and Klamerus, {Karen J} and Katherine Chi-Burris and Eric Yan and Paggiarino, {Dario A} and Irit Rosenblatt and Roger Aitchison and Erlich, {Shai S} and {DEGAS Clinical Study Group}",
year = "2012",
doi = "10.1167/iovs.12-9961",
language = "English",
volume = "53",
pages = "7666--74",
journal = "Investigative ophthalmology & visual science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "12",
}