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Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

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@article{ae8de5eafcca41fb879ab91871c7d56b,
title = "Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study",
abstract = "Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).",
author = "{Martini Clausen}, Malene and Hansen, {Anders E} and {Af Rosenschold}, {Per Munck} and Andreas Kjaer and Kristensen, {Annemarie Thuri} and Fintan McEvoy and Engelholm, {Svend A}",
year = "2013",
doi = "10.1186/1748-717X-8-262",
language = "English",
volume = "8",
pages = "262",
journal = "Radiation Oncology",
issn = "1748-717X",
publisher = "BioMed Central Ltd",

}

RIS

TY - JOUR

T1 - Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors

T2 - a feasibility study

AU - Martini Clausen, Malene

AU - Hansen, Anders E

AU - Af Rosenschold, Per Munck

AU - Kjaer, Andreas

AU - Kristensen, Annemarie Thuri

AU - McEvoy, Fintan

AU - Engelholm, Svend A

PY - 2013

Y1 - 2013

N2 - Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).

AB - Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).

U2 - 10.1186/1748-717X-8-262

DO - 10.1186/1748-717X-8-262

M3 - Journal article

VL - 8

SP - 262

JO - Radiation Oncology

JF - Radiation Oncology

SN - 1748-717X

ER -

ID: 43157849