Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

Malene Martini Clausen; Anders E Hansen; Per Munck Af Rosenschold; Andreas Kjaer; Annemarie Thuri Kristensen; Fintan McEvoy; Svend A Engelholm

doi:10.1186/1748-717X-8-262

Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

Malene Martini Clausen, Anders E Hansen, Per Munck Af Rosenschold, Andreas Kjaer, Annemarie Thuri Kristensen, Fintan McEvoy, Svend A Engelholm

Afdeling for Klinisk Fysiologi og Nuklearmedicin

15 Citationer (Scopus)

Abstract

Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).

Originalsprog	Engelsk
Tidsskrift	Radiation Oncology
Vol/bind	8
Sider (fra-til)	262
ISSN	1748-717X
DOI	https://doi.org/10.1186/1748-717X-8-262
Status	Udgivet - 2013

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10.1186/1748-717X-8-262

Citationsformater

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title = "Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study",

abstract = "Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).",

author = "{Martini Clausen}, Malene and Hansen, {Anders E} and {Af Rosenschold}, {Per Munck} and Andreas Kjaer and Kristensen, {Annemarie Thuri} and Fintan McEvoy and Engelholm, {Svend A}",

year = "2013",

doi = "10.1186/1748-717X-8-262",

language = "English",

volume = "8",

pages = "262",

journal = "Radiation Oncology",

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publisher = "BioMed Central Ltd",

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TY - JOUR

T1 - Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors

T2 - a feasibility study

AU - Martini Clausen, Malene

AU - Hansen, Anders E

AU - Af Rosenschold, Per Munck

AU - Kjaer, Andreas

AU - Kristensen, Annemarie Thuri

AU - McEvoy, Fintan

AU - Engelholm, Svend A

PY - 2013

Y1 - 2013

N2 - Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).

AB - Glycolytic activity and hypoxia are associated with poor prognosis and radiation resistance. Including both the tumor uptake of 2-deoxy-2-[18 F]-fluorodeoxyglucose (FDG) and the proposed hypoxia tracer copper(II)diacetyl-bis(N4)-methylsemithio-carbazone (Cu-ATSM) in targeted therapy planning may therefore lead to improved tumor control. In this study we analyzed the overlap between sub-volumes of FDG and hypoxia assessed by the uptake of 64Cu-ATSM in canine solid tumors, and evaluated the possibilities for dose redistribution within the gross tumor volume (GTV).

U2 - 10.1186/1748-717X-8-262

DO - 10.1186/1748-717X-8-262

M3 - Journal article

C2 - 24199939

SN - 1748-717X

VL - 8

SP - 262

JO - Radiation Oncology

JF - Radiation Oncology

ER -

Dose escalation to high-risk sub-volumes based on non-invasive imaging of hypoxia and glycolytic activity in canine solid tumors: a feasibility study

Abstract

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