Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Dopamine plasma clearance is increased in piglets compared to neonates during continuous dopamine infusion

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Infectious diseases detected by screening after arrival to Denmark in internationally adopted children

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Predicting respiratory distress syndrome at birth using a fast test based on spectroscopy of gastric aspirates. 2. Clinical part

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Predicting respiratory distress syndrome at birth using fast test based on spectroscopy of gastric aspirates. 1. Biochemical part

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Undocumented migrant children in Denmark present with diverse health needs and sometimes have critical health conditions

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

AIM: Piglets models have often been used to study the effects of dopamine infusion on hypotension in neonates. However, piglets need higher doses of dopamine than neonates to increase blood pressure. We investigated whether this difference was due to interspecific difference in dopamine pharmacokinetics.

METHODS: Arterial blood samples were drawn from six neonates admitted to the neonatal intensive care unit of Copenhagen University Hospital and 20 newborn piglets during continuous dopamine infusion. Furthermore, to estimate the piglet plasma dopamine half-life, blood samples were drawn at 2.5-minute intervals after the dopamine infusion was discontinued. The plasma dopamine content was analysed by high-performance liquid chromatography with electrochemical detection.

RESULTS: The dopamine displayed first-order kinetics in piglets and had a half-life of 2.5 minutes, while the median plasma clearance was 627.9 mL/kg/minute (interquartile range 452.6-1914.4). Both piglets and neonates showed large interindividual variations in plasma clearance, but the median tended to be lower in neonates (384.9, interquartile range 114.2-480.2 mL/kg/minute).

CONCLUSION: Our results suggest that pharmacokinetic differences may explain the interspecific difference in required doses of dopamine infusion to increase blood pressure. This is important when translating the results obtained in piglet models to treating neonatal hypotension with dopamine.

OriginalsprogEngelsk
TidsskriftActa paediatrica
Vol/bind107
Udgave nummer2
Sider (fra-til)249-254
Antal sider6
ISSN1651-2227
DOI
StatusUdgivet - 2018

ID: 52372203