Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Ivar Mendez; Angel Viñuela; Arnar Astradsson; Karim Mukhida; Penelope Hallett; Harold Robertson; Travis Tierney; Renn Holness; Alain Dagher; John Q Trojanowski; Ole Isacson

doi:10.1038/nm1752

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Ivar Mendez, Angel Viñuela, Arnar Astradsson, Karim Mukhida, Penelope Hallett, Harold Robertson, Travis Tierney, Renn Holness, Alain Dagher, John Q Trojanowski, Ole Isacson

387 Citationer (Scopus)

Abstract

Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

Originalsprog	Engelsk
Tidsskrift	Nature Medicine
Vol/bind	14
Udgave nummer	5
Sider (fra-til)	507-9
Antal sider	3
ISSN	1078-8956
DOI	https://doi.org/10.1038/nm1752
Status	Udgivet - maj 2008

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title = "Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years",

abstract = "Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.",

keywords = "Brain Tissue Transplantation, Fetal Tissue Transplantation, Humans, Immunohistochemistry, Male, Middle Aged, Neurons, Parkinson Disease, Positron-Emission Tomography, Treatment Outcome, Tyrosine 3-Monooxygenase",

author = "Ivar Mendez and Angel Vi{\~n}uela and Arnar Astradsson and Karim Mukhida and Penelope Hallett and Harold Robertson and Travis Tierney and Renn Holness and Alain Dagher and Trojanowski, \{John Q\} and Ole Isacson",

year = "2008",

month = may,

doi = "10.1038/nm1752",

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T1 - Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

AU - Mendez, Ivar

AU - Viñuela, Angel

AU - Astradsson, Arnar

AU - Mukhida, Karim

AU - Hallett, Penelope

AU - Robertson, Harold

AU - Tierney, Travis

AU - Holness, Renn

AU - Dagher, Alain

AU - Trojanowski, John Q

AU - Isacson, Ole

PY - 2008/5

Y1 - 2008/5

N2 - Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

AB - Postmortem analysis of five subjects with Parkinson's disease 9-14 years after transplantation of fetal midbrain cell suspensions revealed surviving grafts that included dopamine and serotonin neurons without pathology. These findings are important for the understanding of the etiopathogenesis of midbrain dopamine neuron degeneration and future use of cell replacement therapies.

KW - Brain Tissue Transplantation

KW - Fetal Tissue Transplantation

KW - Humans

KW - Immunohistochemistry

KW - Male

KW - Middle Aged

KW - Neurons

KW - Parkinson Disease

KW - Positron-Emission Tomography

KW - Treatment Outcome

KW - Tyrosine 3-Monooxygenase

UR - https://www.scopus.com/pages/publications/43249085326

U2 - 10.1038/nm1752

DO - 10.1038/nm1752

M3 - Journal article

C2 - 18391961

SN - 1078-8956

VL - 14

SP - 507

EP - 509

JO - Nature Medicine

JF - Nature Medicine

IS - 5

ER -

Dopamine neurons implanted into people with Parkinson's disease survive without pathology for 14 years

Abstract

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