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Does minimal central nervous system involvement in childhood acute lymphoblastic leukemia increase the risk for central nervous system toxicity?

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DOI

  1. Socioeconomic position and maintenance therapy in children with acute lymphoblastic leukemia: A national cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Clinical evidence for a biological effect of epigenetically active decitabine in relapsed or progressive rhabdoid tumors

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Anti-CD19 CAR T cells administration was feasible in a child with primary hepatitis B infection

    Publikation: Bidrag til tidsskriftLetterForskningpeer review

  1. Socioeconomic position and maintenance therapy in children with acute lymphoblastic leukemia: A national cohort study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Asparaginase encapsulated in erythrocytes as second-line treatment in hypersensitive patients with acute lymphoblastic leukaemia

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Characteristics of white blood cell count in acute lymphoblastic leukemia: A COST LEGEND phenotype-genotype study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer

Central nervous system (CNS) involvement in childhood acute lymphoblastic leukemia (ALL) implicates enhanced intrathecal chemotherapy, which is related to CNS toxicity. Whether CNS involvement alone contributes to CNS toxicity remains unclear. We studied the occurrence of all CNS toxicities, seizures, and posterior reversible encephalopathy syndrome (PRES) in children with ALL without enhanced intrathecal chemotherapy with CNS involvement (n = 64) or without CNS involvement (n = 256) by flow cytometry. CNS involvement increased the risk for all CNS toxicities, seizures, and PRES in univariate analysis and, after adjusting for induction therapy, for seizures (hazard ratio [HR] = 3.33; 95% confidence interval [CI]: 1.26-8.82; p = 0.016) and PRES (HR = 4.85; 95% CI: 1.71-13.75; p = 0.003).

OriginalsprogEngelsk
Artikelnummere29745
TidsskriftPediatric Blood & Cancer
Vol/bind69
Udgave nummer7
Sider (fra-til)e29745
ISSN1545-5009
DOI
StatusUdgivet - jul. 2022

Bibliografisk note

© 2022 The Authors. Pediatric Blood & Cancer published by Wiley Periodicals LLC.

ID: 77929911