TY - JOUR
T1 - Does cannabis use affect treatment outcome in bipolar disorder? A longitudinal analysis
AU - van Rossum, Inge
AU - Boomsma, Maarten
AU - Tenback, Diederik
AU - Reed, Catherine
AU - van Os, Jim
AU - EMBLEM Advisory Board, null
N1 - Keywords: Adult; Anticonvulsants; Antipsychotic Agents; Bipolar Disorder; Female; Humans; Inpatients; Interpersonal Relations; Lithium Compounds; Longitudinal Studies; Male; Marijuana Smoking; Medication Adherence; Middle Aged; Outpatients; Personal Satisfaction; Prospective Studies; Severity of Illness Index; Treatment Outcome
PY - 2009
Y1 - 2009
N2 - Research suggests that cannabis use affects negatively on onset and outcome of schizophrenia, but less is known about possible effects in mood disorders. Bipolar in- and outpatients (N = 3459) were enrolled in an observational study. The influence of cannabis exposure on clinical and social treatment outcome measures was examined over the course of 1 year, as well as the effects on these associations of third mediating variables. Over 12 months of treatment, cannabis users exhibited less compliance and higher levels of overall illness severity, mania, and psychosis compared with nonusers. Additionally, cannabis users experienced less satisfaction with life and had a lower probability of having a relationship compared with nonusers. There was little evidence that cannabis-outcome associations were mediated by third variables. An independent impact of cannabis use on psychopathologic outcomes in patients with bipolar disorder was apparent, whereas the impact on social outcomes was modest.
AB - Research suggests that cannabis use affects negatively on onset and outcome of schizophrenia, but less is known about possible effects in mood disorders. Bipolar in- and outpatients (N = 3459) were enrolled in an observational study. The influence of cannabis exposure on clinical and social treatment outcome measures was examined over the course of 1 year, as well as the effects on these associations of third mediating variables. Over 12 months of treatment, cannabis users exhibited less compliance and higher levels of overall illness severity, mania, and psychosis compared with nonusers. Additionally, cannabis users experienced less satisfaction with life and had a lower probability of having a relationship compared with nonusers. There was little evidence that cannabis-outcome associations were mediated by third variables. An independent impact of cannabis use on psychopathologic outcomes in patients with bipolar disorder was apparent, whereas the impact on social outcomes was modest.
U2 - 10.1097/NMD.0b013e31819292a6
DO - 10.1097/NMD.0b013e31819292a6
M3 - Journal article
C2 - 19155808
SN - 0022-3018
VL - 197
SP - 35
EP - 40
JO - Journal of Nervous and Mental Disease
JF - Journal of Nervous and Mental Disease
IS - 1
ER -