Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Do patients with type 2 diabetes mellitus have an increased prevalence of Cushing's syndrome?

Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

DOI

  1. Treatment of modifiable risk factors for foot ulceration in persons with diabetes: a systematic review

    Publikation: Bidrag til tidsskriftReviewForskningpeer review

  2. Guidelines on the prevention of foot ulcers in persons with diabetes (IWGDF 2019 update)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Glucose homeostasis in statin users-The LIFESTAT study

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Oral insulin does not alter gut microbiota composition of NOD mice

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Many clinical features are common for patients with type 2 diabetes mellitus (T2DM) and Cushing's syndrome (CS) such as central obesity, hypertension and dyslipidaemia. Patients with CS often have T2DM. Because T2DM is much more frequent than CS, it is possible that some patients with T2DM have increased production of cortisol and thus represent patients with CS. The aim of this review was to evaluate the prevalence of CS in patients with T2DM. A search was performed in PubMed and Medline. We found seven prospective studies, two case-control studies and two cross-sectional studies. The difficulties in diagnosing subclinical CS is discussed. The most frequent tests for diagnosing CS, late-night salivary cortisol, 1-mg dexamethasone suppression test and urinary free cortisol are discussed and put in relation to the results of the literature found. The observed prevalence of CS in patients with T2DM varies widely between the different studies, ranging from 0-9.4%. This may be due to patient selection, differences in test methodology (including choice of test), cutoff values and different cortisol assays. The true prevalence of CS in T2DM has not been determined. We need more studies investigating the prevalence of CS in T2DM patients. There is a need for developing more specific tests for diagnosing CS in patients with only slightly elevated cortisol secretion and subclinical CS. We suggest that examination for hypercortisolism should only be performed in T2DM patients with a cushingoid appearance and hypertension or truncal obesity or dyslipidaemia.
OriginalsprogEngelsk
TidsskriftDiabetes - Metabolism: Research and Reviews (Print Edition)
Vol/bind28
Udgave nummer3
Sider (fra-til)219-27
Antal sider9
ISSN1520-7552
DOI
StatusUdgivet - 2012

ID: 36904262