Do Ahlbäck scores identify subgroups with different magnitudes of cartilage thickness loss in patients with moderate to severe radiographic osteoarthritis? - Forskning

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Do Ahlbäck scores identify subgroups with different magnitudes of cartilage thickness loss in patients with moderate to severe radiographic osteoarthritis? One-year follow-up data from the Osteoarthritis Initiative

Publikation: Bidrag til tidsskrift › Tidsskriftartikel › peer review

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@article{6851970c11944bb4870d25d0ade676d6,

title = "Do Ahlb{\"a}ck scores identify subgroups with different magnitudes of cartilage thickness loss in patients with moderate to severe radiographic osteoarthritis?: One-year follow-up data from the Osteoarthritis Initiative",

abstract = "OBJECTIVE: Kellgren-Lawrence grades (KLG) are frequently used for patient selection in clinical trials. The Ahlb{\"a}ck radiographic grading system has been developed for moderate and severe knee OA. KLG 3 is comparable to Ahlb{\"a}ck 1 and KLG 4 is subdivided into Ahlb{\"a}ck 2-5. The objective of this study was to investigate if the Ahlb{\"a}ck scoring system is able to subdivide patients with moderate to severe knee OA (KLG 3/4) into groups with different sensitivity to change in cartilage thickness.MATERIALS AND METHODS: This study was based on 108 Osteoarthritis Initiative (OAI) participants with KLG 3/4. Baseline KLG scores were available from the OAI database; Ahlb{\"a}ck scores were performed using the same x-rays. Cartilage thickness change in the weight-bearing femorotibial cartilage was analysed from baseline and year 1 3D FLASH MRI for the entire femorotibial joint (FTJ), the medial (MFTC) and the lateral compartment (LFTC) and for the location-independent ordered values 1 and 16 (OV 1/OV 16) representing the subregions with largest loss (OV 1) and gain (OV 16) within each knee.RESULTS: Of the 108 patients, n = 30/78 had KLG 3/4. The corresponding Ahlb{\"a}ck scores (1-5) were n = 30/33/36/9/10. Cartilage thickness changes between Ahlb{\"a}ck groups showed no statistically significant difference for FTJ, MFTC, LFTC and OV 1, but change in OV 16 was significantly higher in Ahlb{\"a}ck 4 knees (p = 0.03) compared to Ahlb{\"a}ck 1-3 knees.CONCLUSION: Radiographic knee OA grading with Ahlb{\"a}ck scores was not superior to KLG for prediction of cartilage thickness loss over 1 year, in patients with moderate and severe knee OA supporting the continuous use of the easier and more widely used KLG.",

keywords = "Cartilage, Articular/diagnostic imaging, Disease Progression, Follow-Up Studies, Humans, Knee Joint/diagnostic imaging, Magnetic Resonance Imaging, Osteoarthritis, Knee/diagnostic imaging, Radiography",

author = "Stine Hangaard and Mikael Boesen and Henning Bliddal and Wolfgang Wirth",

note = "{\textcopyright} 2021. ISS.",

year = "2022",

month = apr,

doi = "10.1007/s00256-021-03871-z",

language = "English",

volume = "51",

pages = "777--782",

journal = "Skeletal Radiology",

issn = "0364-2348",

publisher = "Springer",

number = "4",

}

RIS

TY - JOUR

T1 - Do Ahlbäck scores identify subgroups with different magnitudes of cartilage thickness loss in patients with moderate to severe radiographic osteoarthritis?

T2 - One-year follow-up data from the Osteoarthritis Initiative

AU - Hangaard, Stine

AU - Boesen, Mikael

AU - Bliddal, Henning

AU - Wirth, Wolfgang

PY - 2022/4

Y1 - 2022/4

N2 - OBJECTIVE: Kellgren-Lawrence grades (KLG) are frequently used for patient selection in clinical trials. The Ahlbäck radiographic grading system has been developed for moderate and severe knee OA. KLG 3 is comparable to Ahlbäck 1 and KLG 4 is subdivided into Ahlbäck 2-5. The objective of this study was to investigate if the Ahlbäck scoring system is able to subdivide patients with moderate to severe knee OA (KLG 3/4) into groups with different sensitivity to change in cartilage thickness.MATERIALS AND METHODS: This study was based on 108 Osteoarthritis Initiative (OAI) participants with KLG 3/4. Baseline KLG scores were available from the OAI database; Ahlbäck scores were performed using the same x-rays. Cartilage thickness change in the weight-bearing femorotibial cartilage was analysed from baseline and year 1 3D FLASH MRI for the entire femorotibial joint (FTJ), the medial (MFTC) and the lateral compartment (LFTC) and for the location-independent ordered values 1 and 16 (OV 1/OV 16) representing the subregions with largest loss (OV 1) and gain (OV 16) within each knee.RESULTS: Of the 108 patients, n = 30/78 had KLG 3/4. The corresponding Ahlbäck scores (1-5) were n = 30/33/36/9/10. Cartilage thickness changes between Ahlbäck groups showed no statistically significant difference for FTJ, MFTC, LFTC and OV 1, but change in OV 16 was significantly higher in Ahlbäck 4 knees (p = 0.03) compared to Ahlbäck 1-3 knees.CONCLUSION: Radiographic knee OA grading with Ahlbäck scores was not superior to KLG for prediction of cartilage thickness loss over 1 year, in patients with moderate and severe knee OA supporting the continuous use of the easier and more widely used KLG.

AB - OBJECTIVE: Kellgren-Lawrence grades (KLG) are frequently used for patient selection in clinical trials. The Ahlbäck radiographic grading system has been developed for moderate and severe knee OA. KLG 3 is comparable to Ahlbäck 1 and KLG 4 is subdivided into Ahlbäck 2-5. The objective of this study was to investigate if the Ahlbäck scoring system is able to subdivide patients with moderate to severe knee OA (KLG 3/4) into groups with different sensitivity to change in cartilage thickness.MATERIALS AND METHODS: This study was based on 108 Osteoarthritis Initiative (OAI) participants with KLG 3/4. Baseline KLG scores were available from the OAI database; Ahlbäck scores were performed using the same x-rays. Cartilage thickness change in the weight-bearing femorotibial cartilage was analysed from baseline and year 1 3D FLASH MRI for the entire femorotibial joint (FTJ), the medial (MFTC) and the lateral compartment (LFTC) and for the location-independent ordered values 1 and 16 (OV 1/OV 16) representing the subregions with largest loss (OV 1) and gain (OV 16) within each knee.RESULTS: Of the 108 patients, n = 30/78 had KLG 3/4. The corresponding Ahlbäck scores (1-5) were n = 30/33/36/9/10. Cartilage thickness changes between Ahlbäck groups showed no statistically significant difference for FTJ, MFTC, LFTC and OV 1, but change in OV 16 was significantly higher in Ahlbäck 4 knees (p = 0.03) compared to Ahlbäck 1-3 knees.CONCLUSION: Radiographic knee OA grading with Ahlbäck scores was not superior to KLG for prediction of cartilage thickness loss over 1 year, in patients with moderate and severe knee OA supporting the continuous use of the easier and more widely used KLG.

KW - Cartilage, Articular/diagnostic imaging

KW - Disease Progression

KW - Follow-Up Studies

KW - Humans

KW - Knee Joint/diagnostic imaging

KW - Magnetic Resonance Imaging

KW - Osteoarthritis, Knee/diagnostic imaging

KW - Radiography

UR - http://www.scopus.com/inward/record.url?scp=85111766485&partnerID=8YFLogxK

U2 - 10.1007/s00256-021-03871-z

DO - 10.1007/s00256-021-03871-z

M3 - Journal article

C2 - 34347112

VL - 51

SP - 777

EP - 782

JO - Skeletal Radiology

JF - Skeletal Radiology

SN - 0364-2348

IS - 4

ER -

ID: 74726429

Do Ahlbäck scores identify subgroups with different magnitudes of cartilage thickness loss in patients with moderate to severe radiographic osteoarthritis? One-year follow-up data from the Osteoarthritis Initiative

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