DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

John R B Perry; Yi-Hsiang Hsu; Daniel I Chasman; Andrew D Johnson; Cathy Elks; Eva Albrecht; Irene L Andrulis; Jonathan Beesley; Gerald S Berenson; Sven Bergmann; Stig E Bojesen; Manjeet K Bolla; Judith Brown; Julie E Buring; Harry Campbell; Jenny Chang-Claude; Georgia Chenevix-Trench; Tanguy Corre; Fergus J Couch; Angela Cox; Kamila Czene; Adamo Pio D'adamo; Gail Davies; Ian J Deary; Joe Dennis; Douglas F Easton; Ellen G Engelhardt; Johan G Eriksson; Tõnu Esko; Peter A Fasching; Jonine D Figueroa; Henrik Flyger; Abigail Fraser; Montse Garcia-Closas; Paolo Gasparini; Christian Gieger; Graham Giles; Pascal Guenel; Sara Hägg; Per Hall; Caroline Hayward; John Hopper; Erik Ingelsson; Sharon L R Kardia; Katherine Kasiman; Julia A Knight; Jari Lahti; Debbie A Lawlor; Patrik K E Magnusson; Sara Margolin; kConFab investigators

doi:10.1093/hmg/ddt620

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

John R B Perry, Yi-Hsiang Hsu, Daniel I Chasman, Andrew D Johnson, Cathy Elks, Eva Albrecht, Irene L Andrulis, Jonathan Beesley, Gerald S Berenson, Sven Bergmann, Stig E Bojesen, Manjeet K Bolla, Judith Brown, Julie E Buring, Harry Campbell, Jenny Chang-Claude, Georgia Chenevix-Trench, Tanguy Corre, Fergus J Couch, Angela CoxKamila Czene, Adamo Pio D'adamo, Gail Davies, Ian J Deary, Joe Dennis, Douglas F Easton, Ellen G Engelhardt, Johan G Eriksson, Tõnu Esko, Peter A Fasching, Jonine D Figueroa, Henrik Flyger, Abigail Fraser, Montse Garcia-Closas, Paolo Gasparini, Christian Gieger, Graham Giles, Pascal Guenel, Sara Hägg, Per Hall, Caroline Hayward, John Hopper, Erik Ingelsson, Sharon L R Kardia, Katherine Kasiman, Julia A Knight, Jari Lahti, Debbie A Lawlor, Patrik K E Magnusson, Sara Margolin, kConFab investigators

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54 Citationer (Scopus)

Abstract

The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain

Originalsprog	Engelsk
Tidsskrift	Human Molecular Genetics
Vol/bind	23
Udgave nummer	9
Sider (fra-til)	2490-7
Antal sider	8
ISSN	0964-6906
DOI	https://doi.org/10.1093/hmg/ddt620
Status	Udgivet - 8 jan. 2014

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10.1093/hmg/ddt620

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Perry, J. R. B., Hsu, Y.-H., Chasman, D. I., Johnson, A. D., Elks, C., Albrecht, E., Andrulis, I. L., Beesley, J., Berenson, G. S., Bergmann, S., Bojesen, S. E., Bolla, M. K., Brown, J., Buring, J. E., Campbell, H., Chang-Claude, J., Chenevix-Trench, G., Corre, T., Couch, F. J., ... kConFab investigators (2014). DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Human Molecular Genetics, 23(9), 2490-7. https://doi.org/10.1093/hmg/ddt620

Perry, JRB, Hsu, Y-H, Chasman, DI, Johnson, AD, Elks, C, Albrecht, E, Andrulis, IL, Beesley, J, Berenson, GS, Bergmann, S, Bojesen, SE, Bolla, MK, Brown, J, Buring, JE, Campbell, H, Chang-Claude, J, Chenevix-Trench, G, Corre, T, Couch, FJ, Cox, A, Czene, K, D'adamo, AP, Davies, G, Deary, IJ, Dennis, J, Easton, DF, Engelhardt, EG, Eriksson, JG, Esko, T, Fasching, PA, Figueroa, JD, Flyger, H, Fraser, A, Garcia-Closas, M, Gasparini, P, Gieger, C, Giles, G, Guenel, P, Hägg, S, Hall, P, Hayward, C, Hopper, J, Ingelsson, E, Kardia, SLR, Kasiman, K, Knight, JA, Lahti, J, Lawlor, DA, Magnusson, PKE, Margolin, S & kConFab investigators 2014, 'DNA mismatch repair gene MSH6 implicated in determining age at natural menopause', Human Molecular Genetics, bind 23, nr. 9, s. 2490-7. https://doi.org/10.1093/hmg/ddt620

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title = "DNA mismatch repair gene MSH6 implicated in determining age at natural menopause",

abstract = "The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain ",

author = "Perry, {John R B} and Yi-Hsiang Hsu and Chasman, {Daniel I} and Johnson, {Andrew D} and Cathy Elks and Eva Albrecht and Andrulis, {Irene L} and Jonathan Beesley and Berenson, {Gerald S} and Sven Bergmann and Bojesen, {Stig E} and Bolla, {Manjeet K} and Judith Brown and Buring, {Julie E} and Harry Campbell and Jenny Chang-Claude and Georgia Chenevix-Trench and Tanguy Corre and Couch, {Fergus J} and Angela Cox and Kamila Czene and D'adamo, {Adamo Pio} and Gail Davies and Deary, {Ian J} and Joe Dennis and Easton, {Douglas F} and Engelhardt, {Ellen G} and Eriksson, {Johan G} and T{\~o}nu Esko and Fasching, {Peter A} and Figueroa, {Jonine D} and Henrik Flyger and Abigail Fraser and Montse Garcia-Closas and Paolo Gasparini and Christian Gieger and Graham Giles and Pascal Guenel and Sara H{\"a}gg and Per Hall and Caroline Hayward and John Hopper and Erik Ingelsson and Kardia, {Sharon L R} and Katherine Kasiman and Knight, {Julia A} and Jari Lahti and Lawlor, {Debbie A} and Magnusson, {Patrik K E} and Sara Margolin and {kConFab investigators}",

year = "2014",

month = jan,

day = "8",

doi = "10.1093/hmg/ddt620",

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T1 - DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

AU - Perry, John R B

AU - Hsu, Yi-Hsiang

AU - Chasman, Daniel I

AU - Johnson, Andrew D

AU - Elks, Cathy

AU - Albrecht, Eva

AU - Andrulis, Irene L

AU - Beesley, Jonathan

AU - Berenson, Gerald S

AU - Bergmann, Sven

AU - Bojesen, Stig E

AU - Bolla, Manjeet K

AU - Brown, Judith

AU - Buring, Julie E

AU - Campbell, Harry

AU - Chang-Claude, Jenny

AU - Chenevix-Trench, Georgia

AU - Corre, Tanguy

AU - Couch, Fergus J

AU - Cox, Angela

AU - Czene, Kamila

AU - D'adamo, Adamo Pio

AU - Davies, Gail

AU - Deary, Ian J

AU - Dennis, Joe

AU - Easton, Douglas F

AU - Engelhardt, Ellen G

AU - Eriksson, Johan G

AU - Esko, Tõnu

AU - Fasching, Peter A

AU - Figueroa, Jonine D

AU - Flyger, Henrik

AU - Fraser, Abigail

AU - Garcia-Closas, Montse

AU - Gasparini, Paolo

AU - Gieger, Christian

AU - Giles, Graham

AU - Guenel, Pascal

AU - Hägg, Sara

AU - Hall, Per

AU - Hayward, Caroline

AU - Hopper, John

AU - Ingelsson, Erik

AU - Kardia, Sharon L R

AU - Kasiman, Katherine

AU - Knight, Julia A

AU - Lahti, Jari

AU - Lawlor, Debbie A

AU - Magnusson, Patrik K E

AU - Margolin, Sara

AU - kConFab investigators

PY - 2014/1/8

Y1 - 2014/1/8

N2 - The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain

AB - The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ∼50% of the variation in both age at menarche and menopause, but to date the known genes explain

U2 - 10.1093/hmg/ddt620

DO - 10.1093/hmg/ddt620

M3 - Journal article

C2 - 24357391

SN - 0964-6906

VL - 23

SP - 2490

EP - 2497

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 9

ER -

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

Abstract

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