DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

Magnus Borssén; Jessica Nordlund; Zahra Haider; Mattias Landfors; Pär Larsson; Jukka Kanerva; Kjeld Schmiegelow; Trond Flaegstad; Ólafur Gísli Jónsson; Britt-Marie Frost; Josefine Palle; Erik Forestier; Mats Heyman; Magnus Hultdin; Gudmar Lönnerholm; Sofie Degerman

doi:10.1186/s13148-018-0466-3

DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

Magnus Borssén, Jessica Nordlund, Zahra Haider, Mattias Landfors, Pär Larsson, Jukka Kanerva, Kjeld Schmiegelow, Trond Flaegstad, Ólafur Gísli Jónsson, Britt-Marie Frost, Josefine Palle, Erik Forestier, Mats Heyman, Magnus Hultdin, Gudmar Lönnerholm, Sofie Degerman

Afdeling for Børn og Unge

Abstract

Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.

Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.

Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.

Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.

Originalsprog	Engelsk
Tidsskrift	Clinical Epigenetics
Vol/bind	10
Sider (fra-til)	31
ISSN	1868-7075
DOI	https://doi.org/10.1186/s13148-018-0466-3
Status	Udgivet - 2018

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10.1186/s13148-018-0466-3

Citationsformater

Borssén, M., Nordlund, J., Haider, Z., Landfors, M., Larsson, P., Kanerva, J., Schmiegelow, K., Flaegstad, T., Jónsson, Ó. G., Frost, B.-M., Palle, J., Forestier, E., Heyman, M., Hultdin, M., Lönnerholm, G., & Degerman, S. (2018). DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia. Clinical Epigenetics, 10, 31. https://doi.org/10.1186/s13148-018-0466-3

Borssén, M, Nordlund, J, Haider, Z, Landfors, M, Larsson, P, Kanerva, J, Schmiegelow, K, Flaegstad, T, Jónsson, ÓG, Frost, B-M, Palle, J, Forestier, E, Heyman, M, Hultdin, M, Lönnerholm, G & Degerman, S 2018, 'DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia', Clinical Epigenetics, bind 10, s. 31. https://doi.org/10.1186/s13148-018-0466-3

@article{93dfefe53c07420b8a649f83cfc50ee2,

title = "DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia",

abstract = "Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.",

author = "Magnus Borss{\'e}n and Jessica Nordlund and Zahra Haider and Mattias Landfors and P{\"a}r Larsson and Jukka Kanerva and Kjeld Schmiegelow and Trond Flaegstad and J{\'o}nsson, {{\'O}lafur G{\'i}sli} and Britt-Marie Frost and Josefine Palle and Erik Forestier and Mats Heyman and Magnus Hultdin and Gudmar L{\"o}nnerholm and Sofie Degerman",

year = "2018",

doi = "10.1186/s13148-018-0466-3",

language = "English",

volume = "10",

pages = "31",

journal = "Clinical Epigenetics",

issn = "1868-7075",

publisher = "Springer Verlag",

}

TY - JOUR

T1 - DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

AU - Borssén, Magnus

AU - Nordlund, Jessica

AU - Haider, Zahra

AU - Landfors, Mattias

AU - Larsson, Pär

AU - Kanerva, Jukka

AU - Schmiegelow, Kjeld

AU - Flaegstad, Trond

AU - Jónsson, Ólafur Gísli

AU - Frost, Britt-Marie

AU - Palle, Josefine

AU - Forestier, Erik

AU - Heyman, Mats

AU - Hultdin, Magnus

AU - Lönnerholm, Gudmar

AU - Degerman, Sofie

PY - 2018

Y1 - 2018

N2 - Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.

AB - Background: Few biological markers are associated with survival after relapse of B-cell precursor acute lymphoblastic leukemia (BCP-ALL). In pediatric T-cell ALL, we have identified promoter-associated methylation alterations that correlate with prognosis. Here, the prognostic relevance of CpG island methylation phenotype (CIMP) classification was investigated in pediatric BCP-ALL patients.Methods: Six hundred and one BCP-ALL samples from Nordic pediatric patients (age 1-18) were CIMP classified at initial diagnosis and analyzed in relation to clinical data.Results: Among the 137 patients that later relapsed, patients with a CIMP- profile (n = 42) at initial diagnosis had an inferior overall survival (pOS5years 33%) compared to CIMP+ patients (n = 95, pOS5years 65%) (p = 0.001), which remained significant in a Cox proportional hazards model including previously defined risk factors.Conclusion: CIMP classification is a strong candidate for improved risk stratification of relapsed BCP-ALL.

U2 - 10.1186/s13148-018-0466-3

DO - 10.1186/s13148-018-0466-3

M3 - Journal article

C2 - 29515676

SN - 1868-7075

VL - 10

SP - 31

JO - Clinical Epigenetics

JF - Clinical Epigenetics

ER -

DNA methylation holds prognostic information in relapsed precursor B-cell acute lymphoblastic leukemia

Abstract

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