Forskning
Udskriv Udskriv
Switch language
Region Hovedstaden - en del af Københavns Universitetshospital
Udgivet

Disturbances of consciousness and sleep-wake functions in patients following brainstem lesions

Publikation: Bidrag til tidsskriftKonferenceabstrakt i tidsskriftForskningpeer review

  1. Deep phenotyping of facioscapulohumeral muscular dystrophy type 2 by magnetic resonance imaging

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. More precise phenotyping of cluster headache using prospective attack reports

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Randomized trial of facilitated subcutaneous immunoglobulin in multifocal motor neuropathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Acute endovascular reperfusion treatment in patients with ischaemic stroke and large-vessel occlusion (Denmark 2011–2017)

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  5. Disturbed sleep in cluster headache is not the result of transient processes associated with the cluster period

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  1. Pupillary light responses in type 1 and type 2 diabetics with and without retinopathy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  2. Robust, ECG-based detection of Sleep-disordered breathing in large population-based cohorts

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  3. Long-term health and socioeconomic consequences of childhood and adolescent-onset of narcolepsy

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

  4. Long-term health and socioeconomic outcome of obstructive sleep apnea in children and adolescents

    Publikation: Bidrag til tidsskriftTidsskriftartikelForskningpeer review

Vis graf over relationer
Abstract: Sleep-wake and circadian rhythmicity including several vital functions are regulation by complex interplay between basic structures in the brain: brain stem, thalamus, hypothalamus and basic forebrain. Discrete but interconnected clusters of cells located within the brainstem and hypothalamus comprise the circuits that generate wakefulness, non-rapid eye movement (non-REM) sleep, and REM sleep. The hypocretin system plays a function for wake and REM/NREM regulation including reticular activating system (RAS) projects to brain regions via complex projections via thalamus and forebrain. The circadian system involves suprachiasmatic nucleus (SCN) in the hypothalamic region with projections to several system, including a complex cervical parthway to the pineal gland secreting melatonin. As such several lesions may cause disturbances in these regulatory functions. Examples includes specific lesion in inferior hypothalamic region which may involve SCN (circadian disturbances), the ventrolateral preoptic nucleus or its projections (loss of sleep regulation), bi-thalamic lesions (somnolence), to pontine region (REM regulation disturbances), sublaterodorsal nucleus (REM sleep Behavior Disorder), to the hypocretinergic system (narcolepsy with cataplexy), cervical lesion or pineal gland (abolished melatonin secretion). Such lesions may include neurodegeneration (alpha-synucleinopathies, tauopathies), stroke, tumors, inflammations including autoimmune involvement. Disclosure: Nothing to disclose.
OriginalsprogEngelsk
ArtikelnummerFW10_3
TidsskriftEuropean Journal of Neurology
Vol/bind26
Udgave nummerSuppl. 1
Sider (fra-til)976
Antal sider1
ISSN1351-5101
StatusUdgivet - 2019

ID: 59222234